SOP may also be required when laboratory work involves the use of certain types of hazardous chemicals or physical hazards or when more specific language is required to safely perform a procedure. Examples may include working with a pyrophoric or reactive chemical, changing a pyrophoric gas cylinder, work with a particularly hazardous material, etc.

• When a laboratory engages in an activity or procedure not covered by the chemical hygiene plan.
• Laboratory work involves the use of certain types of hazardous chemicals or physical hazards. Examples may include working with a pyrophoric or reactive chemical, changing a pyrophoric gas cylinder, work with a particularly hazardous material, etc.
• More specific language is required to safely perform a procedure.

Once a SOP is written it must be reviewed and approved by Environment, Health & Safety. After approval, all lab workers using that SOP must be trained on its content and the training must be documented. A copy of the training record must be attached to the SOP when placed in the lab copy of the chemical hygiene plan.

• The PI or Lab Supervisor is responsible for developing written SOPs.
• The PI or Lab Supervisor is responsible for providing training to lab personnel on the SOP.
• Laboratory personnel working autonomously or performing independent research are responsible for developing SOPs appropriate for their own work.