Biorepository Services at the University at Buffalo

• It is an enterprise-wide resource, serving the research community and industry partners through centralized and standardized services for the collection, processing, management and distribution of biological assets.
• The biorepository enables critical clinical science research and diagnostic development, as well as the advancement of precision medicine through deep annotation and “big data” integration.
• It fosters collaborative research and strives to facilitate cross disciplinary and/or multi institutional studies and trials.
  
• The biorepository will be College of American Pathologist (CAP) accredited, Good Laboratory Practice (GLP) and Good Clinical Practice (GCP) certified, and CFR compliant.
• The biorepository program provides biosamples suitable for use in downstream applications with academic, pharmaceutical and biotechnology partners.

• To remain competitive from a grant and/or product development perspective
• Make research dollars go further by not having to recreate/support significant
  infrastructure for biobanking operations
• Ensure regulatory compliance of samples so none are restricted for current and future research 

• Biomaterial collection and logistics
• Biomaterial processing and preservation
• Comprehensive pathology assessment and analysis
• GLP/GCP/GMP sample management and storage
• Enterprise level digital chain of custody for all samples and services

The biorepository program has implemented cutting edge technology and has created a quality program to ensure that all biobank services and facilities ensure:

• Minimal variation in sample quality due to harmonized sample collection
  and processing
• Increased accuracy of biosample identity through functional QC of each sample
• Reliable and seamless integration between sample data and quality control metrics
• Regulatory compliant facilities and processes designed to meet the needs of
  any biosample application

The biorepository program supports four main operations to ensure complete digital and physical chain of custody: collection, processing, storage and distribution.

• Collection – Biospecimen sample collection kits are manufactured to ensure
   reproducible and reliable collection. Through advanced barcode processing and
   scanning each sample is tracked at the time of collection and data transferred into
   the biorepository’s laboratory information management system (e.g. origin of the
   sample, time the sample arrived, etc.)
  
  
• Processing – Automated pre-processing (i.e. blood fractionation,
  pathology services) and processing (i.e. nucleic acid extraction, PBMC processing)
  help minimize variation of primary biosamples and their analytes for banking.
  
  
• Storage – Regulated sample storage environments are available and applied to all
  biosamples based on the sample type specific temperature and environmental
  requirements. All storage environments are highly regulated, monitored 24/7/365,
  supported by complete and continuous back up power, and are supported by
  redundant freezers for uninterrupted storage.  This critical piece of the service
  workflow ensures sample quality until the time any sample is requested for use.
  
  
• Distribution – The success of any biorepository is the use of the samples it houses.
  In addition, the ability to retrieve samples in a safe and timely manner is a critical
  component to the biobank service set.  Due to high quality sample storage
  information in the biobank LIMS and the utilization of automation friendly storage
  vessels the UB Biobank can support high volume sample requests on a
  moment’s notice.