Combating Antimicrobial Resistance in the Environment

AMR team with partners from icddr,b.

AMR team with partners from icddr,b in Bangladesh

With a projected 10 million deaths per year, antimicrobial resistant pathogens are predicted to be the leading cause of death worldwide by 2050. Pharmaceutical development cannot keep pace with the problem. To combat these threats before they reach cities, hospitals, and homes, we work with international partners such as the icddr,b seeking out and deterring resilient pathogens in the farms, aquacultures, wastewaters, and other ecologies from which they spread.

What is Antimicrobial Resistance?

By Diana Aga

According to the WHO, Antimicrobial Resistance (AMR) is an increasingly serious threat to global public health that requires action across all government sectors and society. Without effective antibiotics, prevention and treatment of infections caused by bacteria, parasites, viruses and fungi and the success of major surgery and cancer chemotherapy would be compromised. Health care costs would increase as length of stay in normal and intensive care increases. The rise of antibiotic resistance is a global health crisis; it is an increasingly serious threat to global public health that requires action across all government sectors and society.

The emergence and spread of AMR outside hospitals can be exacerbated by various environmental factors such as the continuous discharge of antimicrobial drug residues, antibiotic resistance genes, and antibiotic resistant bacteria from hospital, municipal, and agricultural wastewaters. In addition, the widespread non-clinical use of antimicrobials in apple and pear orchards, aquaculture, and animal production can promote the development of AMR in commensal bacteria, which may later transfer antibiotic resistance genes to pathogenic bacteria that will eventually infect humans. To combat the spread of antibiotic resistant pathogens, the AMR Team will comprehensively investigate the environmental sources and drivers of AMR, and advance the methods of global AMR surveillance.

Videos and Webinars

The Public Health Impact of Intersecting Resistomes among Animals, Humans and the Environment | Dr. David G. White
The Public Health Impact of Intersecting Resistomes among Animals, Humans and the Environment David G. White
Developing Computational Resources for Mining Microbiome Data for Antibiotic Resistance Posed Health Threat: Insights from Bioinformatics Analyses | Dr. Liqing Zhang
Developing Computational Resources for Mining Microbiome Data for Antibiotic Resistance Posed Health Threat: Insights from Bioinformatics Analyses Dr. Liqing Zhang
“Antibiotic resistance is a global problem, and a lot of researchers are trying to fight it by creating new drugs...we are looking at the problem from a different angle: We are trying to prevent its spread.”

Diana Aga, Henry M. Woodburn Professor of Chemistry

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Faculty Fellows

Shamim Islam

Lead, Antimicrobial Resistance Team; Clinical Assistant Professor

Pediatrics

Women and Children‘s Hospital of Buffalo, Division of Infectious Diseases, 219 Bryant Street

Phone: 716-878-7290

Email: shamimis@buffalo.edu

Diana Aga

Henry M. Woodburn Professor of Chemistry; Director of Graduate Studies

Department of Chemistry

611 Natural Sciences Complex

Phone: 716-645-4220

Email: dianaaga@buffalo.edu

Jared Aldstadt

Associate Professor

Department of Geography

117 Wilkeson Quad

Phone: 716-645-0481

Email: geojared@buffalo.edu

John Crane

Professor of Medicine; Adjunct Professor of Micro & Immunol. and of Pharmacol & Tox.

Department of Medicine

317 Biomedical Research Building

Phone: 716-829-2676

Email: jcrane@buffalo.edu

Lauren Sassoubre

Former Assistant Professor

Department of Civil, Structural, and Environmental Engineering

Gail Willsky

Associate Professor

Biochemistry

140 Farber Hall

Phone: 716-829-2969

Email: gwillsky@buffalo.edu

Our work is done in collaboration with many talented community partners. We list these partners on the affiliated project pages.