To explore the proteomics of the SLOS rat model, the UB researchers, led by co-corresponding author Jun Qu, associate professor in the Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, and the Department of Ophthalmology, used ion-current-based proteomic profiling, a relatively new and sophisticated methodology for studying proteins.
“This paper demonstrates that ion-current-based proteomic profiling is superior to conventional methods and could be broadly applicable to more common diseases, such as diabetes, cardiovascular disease, Alzheimer’s disease and age-related macular degeneration,” says Fliesler.
Proteomic profiling is a method of studying differences in protein expression. Qu’s lab is one of the national leaders in proteomic profiling on a large scale. The sophisticated methodology he and colleagues have developed was a key factor in the success of this research. The technique provides coverage for many more proteins than conventional techniques, especially for numerous membrane-associated retina proteins.
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“Through the collaboration with UB, I got the first IRB approval for acquiring human tissues for our experiment.”
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