UB's Institutional Animal Care and Use Committee (IACUC)
procedures and guidelines follow nationally established standards
to ensure the university's animal research and education is ethical
Keep the following in mind when performing multiple surgeries on
- The nature of the protocol achieves the desired physical or
- There is no other alternative available.
- The surgical procedure is needed to create the animal
- Sufficient time between surgeries is allowed for proper
- Written scientific justification is provided to and
approved by the IACUC.
Avoid prolonged restraint unless it is essential for
achieving the research objectives.
- Keep the period of restraint to the minimum required to
accomplish the research objective.
- Give animals training to adapt to equipment and
- Provide for observation of the animal at appropriate
- Seek and provide veterinary care if you see lesions or
signs of illness.
- Restraint devices are not to be considered normal methods of
- Don't use restraint simply as a convenience in handling or
Protocols involving food/water restrictions must include
the following provisions:
- You must scientifically justify food/water restrictions for
research purposes and establish a program that monitors the
physiologic and behavior indexes.
- Minimally, you must maintain daily logs of food or water
intake, recording body weight at least once a week.
- Clearly define specific criteria that would trigger
an animal’s early removal from the study.
- For food restrictions, pay special attention to ensure
animals are consuming a balanced diet.
- For conditioned-response protocols, we recommend use of a
highly preferred food or fluid as positive-reinforcement rather