The goal of the Community of Scholars (COS) Seminar Series is to provide an opportunity for attendees to learn about topics addressing health disparities and clinical and translational research, which are central components of our Clinical and Translational Science Award (CTSA). Attendees from all disciplines including medicine, nursing, dentistry, public health, and pharmacy are invited to attend.
Department of Pathology and Laboratory Medicine
Division of Experimental Pathology
Department of Urology
Department of Surgery
Pennsylvania State University
In this seminar, David DeGraff, PhD will discuss the Implications of Tumor Heterogeneity in Bladder Cancer on Immunotherapy. As cancers arise from the bladder urothelium often exhibit lineage plasticity with regions of urothelial carcinoma adjacent to or admixed with regions of divergent histomorphology. In addition to the fact that divergent histomorphology is associated with reduced response to systemic immunotherapy. In this presentation, Dr. DeGraff will discuss the integrated genomic analyses of mixed histology bladder cancers to identify drivers of tumor heterogeneity. Furthermore, Dr. DeGraff will show how these mechanisms possibly contribute to immunotherapy resistance.