CTSI Distinguished Seminars feature important topics in clinical and translational science presented by outstanding, and sometimes world-renowned, speakers.
Through the Seminar Series, UB's Clinical and Translational Science Institute is partnering with the five health sciences schools and Roswell Park Comprehensive Cancer Center to sponsor a round of visiting scholars in the forefront of their respective disciplines. The goal is to expose faculty, trainees and students to various pathways in clinical and translational research.
Professor of Pediatrics, Divisions of Human Genetics and Immunobiology
Genetics Chair, Systems Biology
Interim Director, Division of Human Genetics
Director, Center for Circadian Medicine
Cincinnati Children's Hospital Medical Center
University of Cincinnati
This seminar will feature Dr. John B. Hogenesch, whose work on the genetic basis of the mammalian circadian clock has been central to progress in the field of chronobiology.
The past several decades have seen an explosion of growth in mechanistic understanding of circadian clocks in several model organisms and in humans. However, translation of that knowledge into actionable medical interventions has been slow-to-non-existent. Dr. Hogenesch will discuss his group’s efforts to develop circadian medicine in a pediatric hospital. He will talk about their recent progress in understanding the molecular output of the clock in mice and humans, including identifying new opportunities for circadian dosing time in improving drug action – hypothesis-driven, mechanistic circadian medicine. Dr. Hogenesch will talk about his group’s efforts to test these hypotheses prospectively in model organisms and retrospectively in large clinical databases. He will also discuss future opportunities and challenges.