Dysregulated communication between the nervous system and immune system occurs during depressive behavior, chronic pain, and inflammation.
Studies in Dr. Ignatowski’s laboratory are designed to investigate the bidirectional communication between the nervous and immune systems as it relates to the control of depressive behavior, chronic pain, and inflammation. She uses a combination of in vitro cell culture systems, in vivo electrical field stimulation of brain tissue, molecular methods, immunohistochemical and immunofluorescence staining, and behavioral models to address the question of how brain-derived tumor necrosis factor (TNF), a pro-inflammatory cytokine and neuromediator, functions as a modulator of brain-body interactions during neuropathic pain and in the mechanism of action of antidepressant drugs. Additionally, studies involve investigation of neurotransmitter (adrenergic and cholinergic) regulation of TNF production from the peripheral macrophage, a major source of TNF during inflammation.
It is anticipated that at the end of the project, students will have generated data for a poster presentation (at the minimum).
|Length of commitment||Longer than a semester (6-9 months)|
|Start time||Any time|
|In-person, remote, or hybrid? ||In-person|
|Level of collaboration||Small group project (2-3 students)|
|Benefits||Academic Credit, Work Study, Volunteer|
|Who is eligible||All undergraduate students|
Students participating in this project might be interested in and eligible for the Goldwater Scholarship and the National Science Foundation Graduate Research Fellowship. Connect with the Office of Fellowships and Scholarships to learn more.
Once you begin the digital badge series, you will have access to all the necessary activities and instructions. Your mentor has indicated they would like you to also complete the specific preparation activities below. Please reference this when you get to Step 2 of the Preparation Phase.
Pathology and Anatomical Sciences