Installation of the university’s logo in August was one clear sign—literally—that the new downtown home for the Jacobs School of Medicine and Biomedical Sciences was nearing completion. A crane hoisted the 800-pound, 7-foot-tall and 13-foot-wide aluminum-clad interlocking “UB” to its towering spot about 140 feet up the building’s Main Street facade, abutting the school’s name. The big blue characters stand out clearly against the structure’s clay-colored “skin.” At night they even glow, marking a new beacon in medicine for Buffalo and beyond.