Projects work toward the development of novel drug and cell therapy for the treatment of demyelinating diseases such as Multiple Sclerosis (MS) and myelin diseases of children such as leukodystrophies.
Our lab’s research is focused on the development of neural stem and progenitor cells in the human brain. Our long term goal is the development of novel drug and cell therapy for the treatment of demyelinating diseases such as Multiple Sclerosis (MS) and myelin diseases of children such as leukodystrophies. Human glial progenitors are a type of stem or progenitor cell that can give rise to astrocytes and oligodendrocytes in the brain. These cells are important regulators of nervous system signal transduction and regulate many physiological processes, for example oligodendrocytes are responsible for the production of the axon insulating sheath known as myelin. Oligodendrocyte progenitors are very important in human diseases as they are can elicit a repair process known as remyelination which replaces lost myelin in the adult brain. Undergraduate research in the Sim lab will vary depending on the assigned project but will typically involve immunofluorescence assessment of cell and tissue cultures and brains of mice transplanted with human cells. Students will be expected to shadow and assist other lab members (graduate students and staff) while learning techniques and then assigned semi-independent projects. Previous students have received research awards, attended national scientific meetings, and several have advanced to graduate study at UB and elsewhere.
The specific outcomes of this project will be identified by the faculty mentor at the beginning of your collaboration.
|Length of commitment||To be determined by student/mentor|
|Start time||Fall, Spring, Summer|
|In-person, remote, or hybrid? ||In-person|
|Level of collaboration||To be determined by student/mentor|
|Benefits||Academic Credit, Volunteer, Work Study|
|Who is eligible||All students|
Students participating in this project might be interested in and eligible for the Goldwater Scholarship and the National Science Foundation Graduate Research Fellowship. Connect with the Office of Fellowships and Scholarships to learn more.
Associate Professor; Neuroscience Program Director
Pharmacology and Toxicology
955 Main St., Room 3256, Jacobs School of Medicine and Biomedical Sciences
Phone: (716) 829-2151
The specific preparation activities for this project will be customized through discussions between you and your project mentor. Please be sure to ask them for the instructions to complete the required preparation activities.
Neuroscience, Pharmacology and Toxicology