We will examine the effect of various drugs on apoptosis signaling in microglia and neuroinflammation.
Brain cells express specialized pattern-recognition receptors (PRRs) that are capable of triggering inflammatory pathways and can recognize pathogen-associated molecular patterns (PAMPs), or host-derived endogenous molecules, called danger or damage-associated molecular patterns (DAMPs). We evaluate the expression of PAMPs and DAMPs in brain cells treated with various drugs and HIV proteins and Amyloid peptides.
The predominant signatures of apoptosis include the loss of cell volume, or cell shrinkage, nuclear condensation, internucleosomal DNA fragmentation, and apoptotic body formation. We examine the effect of various drugs of abuse on apoptosis signaling in microglia and neuroinflammation and various mechanisms associated with neuroinflammation.
We hope that the student will a make a sufficient contribution to earn a co-authorship on an scientific abstract and manuscript.
|Length of commitment||Longer project if student is productive|
|Start time||Fall, Summer|
|Level of collaboration||Individual student project|
|Who is eligible||Seniors|
|Support||Funding is available after the completion of the preparation badge. See below.|
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