Students will engage in researching magnetic resonance imaging (MRI) , helping to develop iron MRI contrast agents, making measurements, fitting data, and preparing samples for MRI studies.
Magnetic resonance imaging (MRI) is a clinically important diagnostic procedure, with about half of MRI scans using contrast agents in order to better image differences in tissue. Nearly all clinically used contrast agents contain gadolinium, yet a large proportion of patients in the US population (ca 30%) are considered at risk for being given gadolinium contrast agents. The proposed research entails the development of iron MRI contrast agents as alternatives for gadolinium. These iron based MRI contrast agents function in the same manner as do the gadolinium agents and are synthesized as coordination complexes that contain macrocyclic ligands. Students will participate by synthesizing and characterizing Fe(III) complexes, making measurements of water proton relaxation by NMR spectroscopy, fitting of the data, and by preparation of samples for MRI studies.
The specific outcomes of this project will be identified by the faculty mentor at the beginning of your collaboration.
|Length of commitment||To be determined by student/mentor|
|Start time||Fall, Spring, Summer|
|In-person, remote, or hybrid? ||In-person|
|Level of collaboration||To be determined by student/mentor|
|Who is eligible||Courses in general and organic chemistry. Inorganic chemistry is preferred but not necessary.|
Students participating in this project might be interested in and eligible for the Goldwater Scholarship and the National Science Foundation Graduate Research Fellowship. Connect with the Office of Fellowships and Scholarships to learn more.
The specific preparation activities for this project will be customized through discussions between you and your project mentor. Please be sure to ask them for the instructions to complete the required preparation activities.