Please join us on Monday, November 28th for a GEM Work-in-Progress talk presented by Thomas Melendy, PhD, Director of the Witebsky Center for Microbial Pathogenesis & Immunology and Associate Professor of Microbiology & Immunology, and Biochemistry for the Department of Microbiology and Immunology in the Jacobs School of Medicine & Biomedical Sciences.
Title: "Small tumor virus replication: viral helicases and cellular polymerases"
Summary: Human polyomaviruses and papillomaviruses are two families of viruses that infect the majority of humans, and a small percentage of these infections can lead to cancers - altogether these cause over 5% of all human cancers. We have a longstanding interest in how these viruses recruit and utilize cellular DNA synthesis enzymes to replicate their viral genomes, and whether this information can be leveraged for antiviral approaches. The replication of polyomavirus genomes is responsive to cellular DNA damage response pathways to slow down DNA replication forks to allow additional time for DNA repair. Our studies on regulating replication fork progression provide insights into DNA replication stress, a new target for anti-cancer therapeutic approaches.
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Meeting ID: 963 9044 9124
These informal talks are part of the GEM Work-in-Progress series held at 4:00 p.m. on the 4th Monday of each month. Talks will take place remotely via Zoom. The speaker schedule is available on the GEM website: www.buffalo.edu/gem.
GEM is seeking faculty, post-doc and student speakers whose work focuses on genomics, the environment or the microbiome for our GEM Work-In-Progress series! If you would like to present at a GEM Work-in-Progress session, please contact us at email@example.com and we will get you onto the schedule.