CTSI Translational Pilot Studies Program awards 13 new grants for 2020-21

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Published March 31, 2020

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The University at Buffalo’s Clinical and Translational Science Institute (CTSI) has awarded 13 new grants to support innovative translational research projects in Western New York.

The CTSI Translational Pilot Studies Program provides seed money to investigators to assist them in developing promising new technologies and therapeutics from the conceptual stage to clinical studies. In addition, the program emphasizes projects that foster cross-disciplinary collaborations and mentoring relationships.

Recipients of 2020-21 Translational Pilot Studies Program awards are:

Lung and breast cancer prevention by an integrated intervention of maternal smoking cessation and breastfeeding

Principal Investigator: Xiaozhong Wen, MD, PhD, Jacobs School of Medicine and Biomedical Sciences

Co-Investigators: Yukiko Washio, PhD, RTI International; Chi-Chen Hong, PhD, Roswell Park Comprehensive Cancer Center; Faye E. Justicia-Linde, MD, Jacobs School; Chang-Xing Ma, PhD, School of Public Health and Health Professions

Prediction of opioid-related drug combinations using CANDO and a WNY retrospective cohort

Principal Investigator: Ram Samudrala, PhD, Jacobs School of Medicine and Biomedical Sciences

Co-Investigators: Peter Elkin, MD, Jacobs School; Zackary Falls, PhD, Jacobs School; Sarah Mullin, MS, Jacobs School

Maternal oxysterol metabolism during pregnancy

Principal Investigator: Todd C. Rideout, PhD, School of Public Health and Health Professions

Co-Investigators: Kai Ling Kong, PhD, Jacobs School of Medicine and Biomedical Sciences; Xiaozhong Wen, PhD, Jacobs School; Richard W. Browne, PhD, Jacobs School; Vanessa M. Barnabei, MD, PhD, Jacobs School

Impact of children's book about clinical research on research knowledge and intent to participate in research: A demonstration project and pilot study

Principal Investigator: Teresa Quattrin, MD, Jacobs School of Medicine and Biomedical Sciences

Co-Investigators: Renee Cadzow, PhD, D’Youville College; Michelle Urbanczyk, Explore & More — The Ralph C. Wilson, Jr. Children’s Museum; Anna Musun-Miller, Explore & More — The Ralph C. Wilson, Jr. Children’s Museum; Erin O’Byrne, MBA, Jacobs School; May Shogan, International Institute of Buffalo

Feasibility of measuring the salivary microbiome in a prospective cohort of older women

Principal Investigator: Michael J. LaMonte, PhD, School of Public Health and Health Professions

Co-Investigators: Christopher Andrews, PhD, University of Michigan; Hailey R. Banack, PhD, School of Public Health and Health Professions; Michael J. Buck, PhD, Jacobs School of Medicine and Biomedical Sciences; Joshua Gordon, PhD, School of Public Health and Health Professions; Keith Kirkwood, DDS, PhD, School of Dental Medicine; Daniel I. McSkimming, PhD, Genomics, Environment, and Microbiome Community of Excellence; Jean Wactawski-Wende, PhD, School of Public Health and Health Professions

Feasibility of an eHealth educational intervention for African Americans with end-stage kidney disease

Principal Investigator: Liise Kayler, MD, MS, Jacobs School of Medicine and Biomedical Sciences

Co-Investigators: Thomas H. Feeley, PhD, College of Arts and Sciences; Lora Cavuoto, PhD, School of Engineering and Applied Sciences

Drugging gene/pathway dependencies in pancreatic cancer

Principal Investigator: Irwin H. Gelman, PhD, Roswell Park Comprehensive Cancer Center

Co-Investigators: Robert M. Straubinger, PhD, School of Pharmacy and Pharmaceutical Sciences; Christos Fountzilas, MD, Roswell Park Comprehensive Cancer Center; Agnieszka Witkiewicz, MD, Roswell Park Comprehensive Cancer Center

Collaborator: David A. Tuveson, MD, Cold Spring Harbor Laboratory Cancer Center

Mobilizing the immune system to reduce the need for chemotherapy in triple negative breast cancer

Principal Investigator: Shipra Gandhi, MD, Roswell Park Comprehensive Cancer Center

Co-Investigators: Pawel Kalinski, MD, PhD, Roswell Park Comprehensive Cancer Center; Per Basse, MD, PhD, DMSci, Roswell Park Comprehensive Cancer Center

A miniaturized spectrometer imager for super-sensitive sensing of lung cancer biomarkers on a chip

Principal Investigators: Qiaoqiang Gan, PhD, School of Engineering and Applied Sciences; Yun Wu, PhD, Jacobs School of Medicine and Biomedical Sciences and School of Engineering and Applied Sciences

Plasma NETosis signature to predict thrombosis in pancreatic cancer

Principal Investigator: Christos Fountzilas, MD, Roswell Park Comprehensive Cancer Center

Co-Investigators: Brahm Segal, MD, Roswell Park Comprehensive Cancer Center and Jacobs School of Medicine and Biomedical Sciences; Renuka Iyer, MD, Roswell Park Comprehensive Cancer Center; Alok Khorana, MD, Cleveland Clinic; Han Yu, PhD, Roswell Park Comprehensive Cancer Center

Data analytic models will improve prediction of symptomatic vasospasm after subarachnoid hemorrhage

Principal Investigator: Jason Davies, MD, PhD, Jacobs School of Medicine and Biomedical Sciences

Co-Investigator: Ciprian N. Ionita, PhD, Jacobs School

Senior Faculty: Stephen Rudin, PhD, Jacobs School; Adnan H. Siddiqui, MD, PhD, Jacobs School

Repurposing Tamoxifen for triple negative breast cancer

Principal Investigator: Gokul M. Das, PhD, Roswell Park Comprehensive Cancer Center

Co-Investigators: Scott I. Abrams, PhD, Roswell Park Comprehensive Cancer Center; Kazuaki Takabe, MD, PhD, Roswell Park Comprehensive Cancer Center; Thaer Khoury, MD, PhD, Roswell Park Comprehensive Cancer Center; Kristopher M. Attwood, PhD, Roswell Park Comprehensive Cancer Center; Robert Straubinger, PhD, School of Pharmacy and Pharmaceutical Sciences

Optimization of the ‘Vulvodyne’ — a prototype device for improved diagnosis and treatment of vulvodynia

Principal Investigator: Vanessa M. Barnabei, MD, PhD, Jacobs School of Medicine and Biomedical Sciences

Co-Investigators: Glenna C. L. Bett, PhD, Jacobs School; Randall L. Rasmusson, PhD, Jacobs School

Funding for the CTSI Translational Science Pilot Studies Program is provided by: UB’s Office of the Provost, Office of the Vice President for Research and Economic Development, and Office of the Vice President for Health Sciences; Roswell Park Comprehensive Cancer Center; and the deans of UB’s Jacobs School of Medicine and Biomedical Sciences, School of Dental Medicine, School of Pharmacy and Pharmaceutical Sciences, School of Engineering and Applied Sciences, School of Public Health and Health Professions, and School of Nursing.