In Vitro Studies of Cultured Kidney Cells

drawn diagram of a cell.

Both primary cultures of kidney proximal tubule cells, which express differentiated functions observed in vitro, and established cell lines will be studied.

Students will discover new signal transduction pathways in kidney disease and cancer.

Project description

Students will be provided the opportunity for in-depth independent undergraduate research to study signal transduction mechanisms controlling the growth and differentiation of cultured kidney tubule epithelial cells in a hormonally defined, serum-free medium. Underlying methods are in the areas of Cell and Molecular Biology, Genetics, and Biochemistry. The effects of hormones and growth factors on growth, development and differentiated functions will be examined. Projects are relevant to understanding the basis of renal diseases including renal cancer.

Project outcome

Students will develop hypotheses, and design experiments to test their hypotheses, and make an original contribution. Students will learn to analyze their results, and present their results, and determine whether the results are consistent with their hypotheses.

Project details

Timing, eligibility and other details
Length of commitment Commitments range from a semester, the academic year, and summer sessions.
Start time Anytime
Level of collaboration Generally students have individual projects but may collaborate with other students.
Benefits  Academic credit
Who is eligible Perspective students should have a course background in cell and molecular biology, as well as basic laboratory courses in such topics as chemistry, biochemistry and/or genetics.
Support Funding is available after the completion of the preparation badge. See below.

Project mentor

Mary Taub


Biochemistry Department

519 Biomedical Research Building, 3435 Main St., Bldg. 26

Phone: (716) 829-3300



To engage with this project, you will work through a series of Project-Based Collaboration digital badges to guide your experience. 

To get started, contact the project mentor using the contact information above to discuss availability and after you’ve received approval, you can start the Project Preparation Digital Badge. Here are helpful tips on how to contact a project mentor

Preparation guidance

Once you have registered for the Project Preparation Digital Badge, you will receive further instructions related to the activities you will need to complete. In addition, you will also complete the following preparation activities for this particular project:

  • Students should read journal articles, such as the linked publication, obtained from Dr. Taub prior to starting their independent study.