Opioid Tolerance, Withdrawal, and Hypersensitivity: In Vitro and In Vivo Models

Klein Lab photo superimposed over cell imaging taken by undergraduate student.

Projects related to cell signaling, in vivo imaging, histology, behavioral experiments, and electrophysiology. Lots to learn! 

Project description

The Klein lab is located in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo. The current focus of Dr. Klein's research revolves around the neural mechanisms of pain and the use of opiates and their downstream pathways to alleviate chronic pain, reduce tolerance, and decrease withdrawal symptoms.

We are a team of interdisciplinary scientists interested in neurobiology, pathophysiology, and translational approaches to address the challenges of novel non-opioid based analgesics and the opioid epidemic. 

Project outcome

This project will provide students with the opportunity to write and submit abstract/posters as well as peer-reviewed research papers. 

Project details

Timing, eligibility and other details
Length of commitment Longer than a semester; 6-9 months
Start time Anytime 
In-person, remote, or hybrid? In-Person Project 
Level of collaboration Individual student project 
Benefits Academic credit
Who is eligible All undergraduate students 

Core partners

Project mentor

Amanda Klein

Associate Professor

Pharmacology and Toxicology

Phone: (716) 829-2453

Email: ahklein2@buffalo.edu

Start the project

  1. Email the project mentor using the contact information above to express your interest and get approval to work on the project. (Here are helpful tips on how to contact a project mentor.)
  2. After you receive approval from the mentor to start this project, click the button to start the digital badge. (Learn more about ELN's digital badge options.) 
Start the Digital Badge

Preparation activities

Once you begin the digital badge series, you will have access to all the necessary activities and instructions. Your mentor has indicated they would like you to also complete the specific preparation activities below. Please reference this when you get to Step 2 of the Preparation Phase. 

Please read the required training checklist and Klein Lab expectations - please ask if there are any questions

Keywords

Pharmacology, Neuroscience, Pain, Imaging, Behavior, Cellular, Molecular