In this project, we will use a variety of pharmacological and sophisticated molecular techniques, including optogenetics, to determine which brain regions and neurotransmitters are responsible for the motivation to consume alcohol.
Our laboratory is focused on understanding the neurobiology responsible for motivated behaviors, with the goal of identifying pathways that may serve as potential targets in treating addiction.
Environmental or external stimuli (cues) can increase the motivation to consume sweet or fatty foods, or to drink alcohol to excess. This may occur when the cue is repeatedly paired with the food or alcohol, and can lead to cravings and seeking out the substance. Under these circumstances, the previously neutral cue takes on "incentive" motivational properties.
Recently we have set up an animal model of incentive cues, in which a rat must pay attention to an audiovisual cue and perform a behavior in order to get a sweet reward. Using this model we have established several important brain regions and pathways that are important for processing reward-related cues.
In this project we will modify this procedure using alcohol as the reward, and use a variety of pharmacological and sophisticated molecular techniques, including optogenetics, to determine which brain regions and neurotransmitters are responsible for the motivation to consume alcohol.
The student will learn basic animal handling techniques, behavioral models, and data collection. Optogenetics is an advanced technique in which light can be used to turn on or off specific neurons in the brain. We will be incorporating this into our model, presenting a unique opportunity for the right student to contribute to a cutting edge project.
The specific outcomes of this project will be identified by the faculty mentor at the beginning of your collaboration.
|Length of commitment||Other: must have availability in morning hours for at 2-3 days, M-F|
|Start time||Fall, Spring, Summer|
|In-person, remote, or hybrid? ||Hybrid|
|Level of collaboration||Other: assist a post-doctoral fellow in their research; potential for an individual project|
|Who is eligible||maturity, ability to identify and work through a problem, reliability, punctuality, ability to work with rates, must be able to adhere to a schedule, must be able to work independently|
Pharmacology and Toxicology
510 Biomedical Research Building
Phone: (716) 829-3790
Once you begin the digital badge series, you will have access to all the necessary activities and instructions. Your mentor has indicated they would like you to also complete the specific preparation activities below. Please reference this when you get to Step 2 of the Preparation Phase.
All students must complete IACUC training for working with animals.
Students must complete lab safety training.
Pharmacology and Toxicology