BUFFALO, N.Y. -- Christopher A. Lipinski, an internationally
renowned scientist in the field of drug discovery, on April 10
presented the University at Buffalo School of Pharmacy and
Pharmaceutical Sciences' inaugural David Chu Lecture.
The lecture honors David C.K. Chu, Distinguished Research
Professor Emeritus in the Department of Pharmaceutical and
Biomedical Sciences, College of Pharmacy, at the University of
Georgia, who received a PhD in medicinal chemistry in 1975 from the
UB School of Pharmacy and Pharmaceutical Sciences.
Chu has published more than 300 drug-discovery related
scientific papers and more than 50 U.S. patents have been awarded
to him. Several of his invented compounds are undergoing clinical
trials in the therapeutic areas of cancer, hepatitis B virus, HIV
and Herpes zoster (shingles).
Chu and his wife, Jane, who received her MS in medicinal
chemistry from UB's pharmacy school, established the David Chu
Lectureship in 2011 to give back to their alma mater. It is one of
several initiatives the couple and their daughters, Susan and
Jackie, hope to fund through their recently created Chu Family
"After 40 years of working in the United States, we fulfilled
the American dream, and in addition to hard work, the major reason
we succeeded was the education we received," Chu said. "Thus, we
believe that giving to education and young students is the most
important investment we can make. We set up the lectureship to help
the aspiring graduate students in the UB pharmacy school. We
believe seminar programs are critical in training graduate
students, exposing them to prominent scientists."
The inaugural lecture by Lipinski was a presentation titled
"Drug Discovery and Chemical Biology: Lessons Learned and Times of
A PhD in physical organic chemistry, Lipinski worked at Pfizer
for more than 20 years, contributing to the discovery of numerous
drug candidates. His primary interests are the design of
bioisosteres, drug physical chemical properties and quantitative
structure activity relationships.
Among his many achievements is a set of rules he published 1n
1997 for the properties of well-absorbed drugs. The publication of
these rules -- known as "Lipinski's Rule of 5" -- is one of the
most highly cited publications in the field of medicinal
Lipinski also has championed a pragmatic, chemistry
end-user-oriented approach to the problem of oral activity
He has more than 265 publications and invited presentations,
and has been issued 18 U.S. patents.