7/19/18

The K12 Faculty Scholar Program in Implementation Science is helping to move biomedical discoveries the last step of the way into health care practice.

1/9/18

A highly competitive, $15 million, four-year NIH grant is helping to jump start state-of-the-art clinical and translational research in Western New York.

Mentored Career Development Awards

7/5/18

We're preparing the next generation of clinical and translational researchers. Programs support outstanding junior faculty and senior fellows.

CTSI Translational Pilot Studies Program

6/21/18

Using local institutional support and an award from the National Center for Advancing Translational Sciences, the CTSI funded 11 projects in the 2018-19 cycle.

Fall 2018 Pilot Studies RFP released

8/6/18

The Fall 2018 Request for Proposals (RFP) for Translational Pilot Studies Projects supported by UB's Clinical and Translational Science Award has been released.

A tradition of life-saving translational science

6/14/18

A UB professor of biochemistry and pediatrics was on Robert Guthrie's team that pioneered newborn screening programs worldwide in the '60s and '70s.

Open Research Office

6/6/18

We bring together researchers and administrators to address topics vital to launching, sustaining and completing a successful clinical or behavioral research project.

A regional commitment to excellence

1/19/18

UB's CTSI brings together scientists from across the Buffalo Translational Consortium, a partnership among 20 leading health care, research and community organizations.

Clinical trials pay dividends for patients

6/21/18

Western New Yorkers are benefitting from the growth of clinical research on the Buffalo Niagara Medical Campus, all led by UB’s health sciences schools.

1/9/18

The vision for UB's CTSI is to improve the health of our community through the development, testing and sharing of novel approaches to health care.

1/10/18

We support the efforts of investigators with the material resources and expert assistance they need to develop, test and implement innovative health care solutions.

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Clinical and Translational Research Support

Community Partners

How you can participate in clinical research

There are many ways members of the public can participate in research, from focus groups to patient advocacy groups to volunteering in a clinical study. Participants report feeling more satisified with their health care and can potentialy gain access to new treatments avaialble only to research volunteers.

NEWS

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Request for proposals released for 2019-20 Translational Pilot Studies awards
8/13/18
UB’s Clinical and Translational Science Institute (CTSI) Translational Pilot Studies program is now accepting Letters of Intent for 2019-20 pilot study applications.
Sowing the seeds of future excellence in biomedical science
8/13/18
The Young Scientist Research Program is a two-week immersive summer school program conducted by the Biology Department at Canisius College for local high school students who may be considering science majors in college.
NIH bioinformatics training grant accepting applications
8/2/18
A five-year, $2.5 million grant awarded last summer to the Department of Biomedical Informatics in the Jacobs School of Medicine and Biomedical Sciences is helping to train a new generation of research leaders in the analysis and interpretation of complex health care datasets.
CTSI Service Request Portal receives upgrade
7/17/18
The prime point of entry for researchers seeking access to the services and resources provided by the University at Buffalo’s Clinical and Translational Science institute (CTSI) is the online Service Request Portal. On June 29, the CTSI unveiled its Service Request Portal version 2.0, which features significant upgrades on both the front end and back end.
What good are medical innovations if they never reach patients? UB researchers have $3 million grant to make sure they do
7/9/18
New drugs and diagnostic tests go through years of clinical trials before being approved. But while regulatory approval is an enormous hurdle, getting through that process doesn’t automatically ensure that patients have access to these medical innovations.
Summer students visit CTRC to learn about clinical and translational science
7/5/18
A group of 66 undergraduate students who are participating in summer programs in the health sciences at UB came to the Clinical and Translational Research Center (CTRC) to learn all about careers in clinical and translational research from experts already working in the field.
CTSI Research Riders on a roll for Roswell Park
7/3/18
The intrepid cyclists of the CTSI Research Riders took to the streets of Western New York to raise money for Roswell Park Comprehensive Cancer Center. The team of 11 CTSI employees, friends and family members raised $4,060.
Topic of next Open Research Office is ‘Research Budgets’
7/2/18
The next series of Open Research Office sessions will provide principal investigators and research coordinators with an expert take on a crucial aspect of the scientific endeavor: planning and managing research budgets.
Study: In MS, disintegrating brain lesions may indicate the disease is getting worse
6/20/18
New findings could alter how doctors predict whose disease will become more severe.
CTSI faculty and staff receive accolades at annual Jacobs School Awards of Excellence
6/19/18
Faculty and staff members from UB’s Clinical and Translational Science Institute (CTSI) were among those recognized at a ceremony following the annual Stockton Kimball Lecture at the Jacobs School of Medicine and Biomedical Sciences on June 6.
Pilot studies co-director named SUNY Distinguished Professor
6/12/18
Steven J. Fliesler, PhD, Meyer H. Riwchun Endowed Chair Professor, vice chair of ophthalmology and co-director of the CTSI Translational Pilot Studies Program, is one of four Jacobs School of Medicine and Biomedical Sciences faculty who have been appointed to the rank of SUNY Distinguished Professor.
Translational research at UB led to life-saving sickle cell test
6/4/18
UB professor of biochemistry and pediatrics was on the team that pioneered newborn screening programs worldwide
CTSI Translational Pilot Study Program 2018-19 awards
5/31/18
UB’s Clinical and Translational Science Institute (CTSI) has awarded new grants that support promising translational research projects in Western New York.
Film screening sparks community conversation on patients' rights
5/11/18
A screening of the film "The Immortal Life of Henrietta Lacks" followed by a panel discussion was meant to build trust between clinical-translational researchers and members of the surrounding community.
Open Research Office bridges gap between clinical researchers and regulators
5/1/18
A diverse group of clinical and behavioral investigators and research coordinators came to UB’s South Campus in April for the third Open Research Office session.
Buffalo’s health disparities are the focus of community-wide conference hosted by UB
4/18/18
Community activists, scholars, clergy and members of the public will gather April 28 at the Jacobs School of Medicine and Biomedical Sciences to discuss Buffalo's health dispartities.
Translating translational science for public audiences
4/16/18
A trio of clinical and translational research experts spoke at the March 26 Scientific Communications Core Competency Workshop, the fifth out of six workshops in the series offered by the CTSI’s Workforce Development core.
Local, national leaders report on progress at UB’s Clinical and Translational Science Institute
4/10/18
Christopher P. Austin, director of the National Institutes of Health’s (NIH) National Center for Advancing Translational Sciences (NCATS), recognizes that translational science has a problem.
Participation in clinical trial helps young woman take control of her diabetes — and her life
4/8/18
A renewed commitment to advancing research by UB and its partners on the Buffalo Niagara Medical Campus has led to an increase in the number of local clinical studies, giving more Western New York patients the benefit of cutting-edge treatments that have significantly improved their lives.
Workforce Development core director to present final workshop in new Cultural Diversity series
3/20/18
“Enhancing Workforce Excellence and Cultural Diversity by Broadening Participation and Professional Development” will present approaches to increasing diversity and enhancing excellence in both educational programs and the translational research workforce.
Study: For soldiers who have served in combat, perceptions strongly influence resiliency
3/16/18
Marriage satisfaction helped soldiers better deal with trauma from combat and resulted in lower levels of alcohol problems
CTSI Translational Science Pilot Studies Program awards 11 new grants for 2018-19
3/8/18
The University at Buffalo’s Clinical and Translational Science Institute (CTSI), with local institutional support and an award from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, has awarded 11 new grants to support promising translational research projects in Western New York.
Professional Development Workshop Series launched
3/8/18
The CTSI Professional Development Workshop Series kicks off on Wednesday, March 14, with a presentation titled, "Team Science.”
Columbia informatics expert reports on integrative data techniques for screening drug interactions
3/8/18
The February 1 Clinical and Translational Science Institute (CTSI) Seminar Series addressed the topic of “Observational data for biomedical discovery.”
KL2 Scholar joins Department of Medicine faculty
2/20/18
Nikhil Satchidanand, PhD, one of the first KL2 Scholars in the University at Buffalo Clinical and Translational Science Award-linked KL2 Mentored Career Development Award (MCDA) program, has joined the faculty of the Jacobs School of Medicine and Biomedical Sciences Department of Medicine as an assistant professor, it was announced in February.
Two new BTC Scholars welcomed
2/20/18
This month UB’s Clinical and Translational Science Institute (CTSI) welcomed two new scholars to the ranks of the Buffalo Translational Consortium (BTC) Mentored Career Development Award (MCDA) program.
Winners of 2017 BTC Clinical Research Achievement Awards announced
2/14/18
Two publications in prestigious, peer-reviewed journals which explore treatments for substance use disorders were selected as winners of the Buffalo Translational Consortium 2017 Clinical Research Achievement Awards.
CTSI Research Table matches patient volunteers with research teams
2/7/18
A unique partnership between two BTC partners is closing the gap between medical research and practice.
Statistical Workshop Series addresses multiple core competencies in translational research
2/7/18
The CTSI Statistical Workshop Series, which began in September and continues through May, includes the following core competencies: statistical approaches, study design, sources of error, research questions and literature critique.
Antioxidant therapy prevents devastating vision loss when added to standard-of-care on rare birth defect
2/6/18
Findings suggest more effective potential therapies for Smith-Lemli-Opitz Syndrome
Workforce Development Core introduces 2018 KL2 and BTC Scholars cohort
1/23/18
The UB CTSI Workforce development core is pleased to introduce the 2018 KL2 and BTC Scholars cohort.
Four new Core Competency Workshop Series launched so far this academic year
1/23/18
The Workforce Development core of the UB Clinical and Translational Science Institute (CTSI) has launched four new Core Competency Workshop Series since the start of the academic year last fall.
Dubocovich receives inaugural ACNP Minority Mentoring Award
1/22/18
Margarita L. Dubocovich, PhD, director of the UB CTSI Workforce Development core and the program lead and principle investigator of the CTSI’s KL2 program, has been awarded the inaugural Dolores Shockley Minority Mentoring Award from the American College of Neuropsychopharmacology (ACNP).
Applications open for Innovation Lab on ‘Lifestyle Interventions that Last’
12/28/17
Innovation Labs are a facilitated five-day collaborative journey in planning creative and audacious new solutions.
New downtown medical school officially opens
12/12/17
The new building allows UB to train more doctors to alleviate physician shortages, achieve breakthroughs in biomedical research and transform health care in Buffalo.
CTRC pine tree provides focal point of Adopt-a-Family gift drive
12/5/17
If you’ve ever visited the fifth-floor atrium of the Clinical and Translational Research Center (CTRC), odds are you’ve noticed a large pine tree growing in the corner over by the north-facing windows.
UB, Vanderbilt partner to test efficacy of interdisciplinary team science
12/4/17
Innovation Labs bring together early-career scholars with experienced mentors to drive novel solutions to grand challenges in translational research.
Community Engagement Workshop Series 2017-2018
11/20/17
The CTSI Workforce Development Core, Community Engagement Core and the KL2 Mentored Career Development Program are pleased to announce the Clinical and Translational Research Core Competencies on Community Engagement.
An important announcement for all clinical researchers
11/13/17
Starting January 25, 2018, NIH-defined clinical trial applications must be submitted using a Funding Opportunity Announcement (FOA) that is worded specifically for clinical trials. In the past, clinical trial applications could be submitted for FOAs that were not identified as being clinical-trial specific. Submitting to the wrong FOA will lead to rejection of your application.
Colleagues continue research project of nursing school scholar who died in June car accident
11/9/17
She was developing a promising treatment for PTSD among urban youth when tragedy struck. Now her research partners are working to keep her legacy alive.
Translational Teamwork Workshop Series 2017-18
11/9/17
The CTSI Workforce Development Core and the Collaboration and Team Science Core are pleased to announce the Clinical and Translational Research Core Competencies on Translational Teamwork.
Cultural Diversity Workshop Series 2017-2018
11/9/17
The CTSI Workforce Development Core and the KL2 Mentored Career Development Program are pleased to announce a Clinical and Translational Research Core Competencies series on cultural diversity.
BNMC opens doors to neighborhood for ‘Treats, Tricks and Discoveries’
11/1/17
An enthusiastic crowd of at least 175 local trick-or-treaters and their families turned out for the first-ever “Tricks, Treats and Discoveries: Family Fun and Learning Fair,” held October 28 in the Educational Opportunity Center on the Buffalo Niagara Medical Campus (BNMC).
Central Study Registration and scientific review are mandatory as of November 13, 2017
11/1/17
The UB Clinical Research Office announced that effective Monday, November 13, 2017, two new initiatives to facilitate and support clinical research across UB will be initiated: Central Study Registration (CSR) and Department/School Scientific Review.
Results of 2015-16 CTSI pilot studies presented at research colloquium
10/27/17
One of the main goals of UB’s Clinical and Translational Science Institute (CTSI) is to advance clinical and translational research that will improve the health and well-being of people living in Western New York, with a special emphasis on reducing the health disparities experienced by many in our community, including underrepresented minority groups and the poor.
CTRC Seminar Series 2017-18
10/20/17
SCHEDULE
CTSI seeks input from Buffalo community
10/17/17
People who participate in clinical trials are happier with their health care and have better health outcomes.
Distinguished alum looks to the future of Buffalo’s academic medical center
10/16/17
James Marks, MD, MPH, a 1973 graduate of UB’s medical school and executive vice president at the Princeton-based Robert Wood Johnson Foundation, returned home during Alumni Weekend in October to talk about the economic impact that academic medical centers can have on a city like Buffalo.
Activity book engages children and families in research
10/6/17
An important goal of UB’s Clinical and Translational Science Institute (CTSI) is to improve the representativeness of research studies, including participants from special populations such as children, the elderly, underrepresented racial and ethnic groups, and people with disabilities.
Davies receives KL2 Mentored Career Development Award
9/20/17
The KL2 award provides research mentoring and career and professional development to junior faculty in health science disciplines engaged in clinical and translational research.
Clinical Research Office relaunches 'Research Roundtable' newsletter
9/19/17
UB's Clinical Research Office started this academic year off with the rededication of the Research Roundtable newsletter.
Working group seeks to extend the depth and functionality of biomedical ontologies
9/14/17
Buffalo has had an “outsized” influence in the field of biomedical ontology over the past 15 years or so
Dental school teams up with CTSI to bring national researcher to Buffalo
9/7/17
The CTSI Seminar Series resumes on October 5 with a presentation co-sponsored by the School of Dental Medicine.
Workforce Development Core announces seminars in ore competencies
9/6/17
The UB CTSI Workforce Development Core is ratcheting up its offering of Core Competencies in Clinical and Translational Research seminars.
Student on CTSA diversity supplement is co-first author on MS study
8/25/17
Jessie J. Polanco, recipient of a 2016 diversity supplement from UB’s Clinical and Translational Science Award (CTSA), was co-first author of a study published August 8 in Stem Cell Reports.
RIA fall seminars series announced
8/15/17
The Fall Seminar Series at the University at Buffalo Research Institute on Addictions will feature national experts on heavy drinking in young adults, dating violence, financing addiction treatment and tobacco use.
UB CTSI director: Cuts to science funding have many ripple effects
8/14/17
Timothy F. Murphy, MD, authored a blog post on the American Federation of Teachers website about how Washington’s anti-science sentiment will hurt research funding for NIH.
Biomedical informatics gets a boost with $2.5 million grant
8/7/17
A new five-year $2.5 million grant to the Department of Biomedical Informatics will train a new cadre of research leaders skilled in analyzing and interpreting big data.
Sharma awarded NIH K08 award to study myocardial fibrosis and heart failure
7/27/17
On July 15, Umesh Sharma, MD, PhD, a CTSI Scholar in the Mentored Career Development Program, was granted a five-year, $986,850 KO8 award.
2017 CTSI Seminar Series resumes in October
7/26/17
The 2017 CTSI Seminar Series, which brings top experts in their respective fields to the University at Buffalo for speaking engagements, returns in October following a summer hiatus.
Pilot study program director tapped to lead top vision and eye organization
7/20/17
Steven J. Fliesler, PhD, has been elected to a leadership post in the Association for Research in Vision and Ophthalmology (ARVO).
Undergrads explore career paths in clinical and translational science
7/19/17
Undergraduate students participating in summer programs in the health sciences at UB were invited to explore careers in clinical and translational research on June 23.
Say hello to 'Translational Spotlight,' the official newsletter of the UB CTSI
7/18/17
Back in April, we asked readers to submit suggestions for a new name for the official newsletter of the UB Clinical and Translational Science Institute.
CTSI Research Riders rock the annual Ride For Roswell
7/6/17
On a beautiful Saturday morning in June, the CTSI Research Riders put their collective pedal power to work for cancer research and treatment at Roswell Park Cancer Institute.
OnCore project is improving clinical research at UB in ways big and small
7/5/17
Roll-out of the university-wide OnCore research management system continues to make progress one year after its first introduction to the UB research community.
RIA director stresses understanding when dealing withdrug addiction
6/21/17
An article in Health about a report from the Los Angeles coroner’s office that found that actress Carrie Fisher had multiple drugs in her system when she died after suffering a heart attack in December. The story features an extensive interview with Kenneth Leonard, who is the director of UB’s Research Institute on Addictions and a CTSI board member.
UB remembers nursing researcher Ellen Volpe
6/12/17
Ellen Volpe, PhD, RN, FNP-BC, assistant professor and researcher in the School of Nursing, died June 8 in a car accident on the Thruway. She was 45.
Program for underrepresented minority students inbiomedical PhD programs wins coveted renewal
6/7/17
UB’s ongoing efforts to recruit underrepresented students in science, technology, engineering and mathematics (STEM) to its PhD programs have received a major boost from the National Institutes of Health, which renewed a five-year, $2.3 million grant to help fully fund scholarships.
Home-Brewed Drugs and the Drug Development Process
6/6/17
Presented by the UB Clinical and Translational Science Institute Drug Development Core
Eiden named chair of study section in NIH’s Center for Scientific Review
6/6/17
BUFFALO, N.Y. – Rina Das Eiden, PhD, senior research scientist in the University at Buffalo’s Research Institute on Addictions, and a Buffalo Translational Consortium partner, has been named chair of the Psychosocial Development, Risk and Prevention Study Section in the National Institute of Health’s Center for Scientific Review.
CTSI Pilot Study awardee working on battery-free pacemaker
5/24/17
Like conventional pacemakers, tiny new leadless pacemakers are designed to work for about 12 years.
Putting surgeons, researchers together is leading to world-class innovations
5/19/17
L. Nelson “Nick” Hopkins is a pioneer in the use of catheters — long, flexible tubes — inserted into the vascular system in the groin and threaded to the brain to treat strokes. The procedure, once called “crazy” by the medical establishment, is now the preferred method in many situations.
Dubocovich honored with President’s Medal
5/18/17
Margarita L. Dubocovich, PhD, SUNY Distinguished Professor of pharmacology and toxicology has been awarded the UB President’s Medal, which recognizes “truly extraordinary effort on behalf the university and the communities we serve,” according to University at Buffalo President Satish K. Tripathi, PhD.
IMSD grant renewal means $2.3 million for students from underrepresented groups
5/15/17
A National Institutes of Health (NIH) training grant aimed at providing professional development resources and mentoring for doctoral students in several UB schools has been renewed for another five years.
A look back, and ahead, at CTSI Annual Forum 2017
5/15/17
The University at Buffalo Clinical and Translational Science Institute (CTSI) held its 2nd Annual Forum on March 28.
CTSI well-represented at annual ACTS Translational Science conference in D.C.
5/15/17
More than 20 UB faculty and staff members were on hand to represent the Clinical and Translational Science Institute (CTSI) at the Translational Science 2017 conference held in Washington, D.C., April 19-21.
Nobel Prize winner shares life experiences with UB audience
5/4/17
The University at Buffalo Jacobs School of Medicine and Biomedical Sciences welcomed a scientific celebrity to campus for the Clinical and Translational Science Institute (CTSI) Seminar Series/O.P. Jones Lecture on May 2.
UB honors medical school alumni in CTSI
5/1/17
Four Western New York medical practitioners were honored on April 28 by the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, including two faculty members associated with the UB Clinical and Translational Science Institute (CTSI).
CTSI Seminar Series: Nobel laureate who pioneered computational biology is guest speaker
4/28/17
The University at Buffalo Clinical and Translational Science Institute (CTSI) Science Seminar Series is pleased to present renowned biophysicist and professor of structural biology Michael Levitt for the 2017 O.P. Jones Lecture entitled, “The Birth and Future of Multiscale Modeling of Macromolecules.”
CTSI Seminar Series welcomes national pain and opioid addiction expert
4/26/17
The theme of the University at Buffalo School of Nursing 2017 Research Day, held on March 31, was opioid addiction treatment and prevention, a public health problem that continues to plague Western New York and many communities throughout the nation.
Genetics are key to hormone therapy lowering risk of broken bones in older women
4/24/17
UB-led study of postmenopausal women finds that those at highest genetic risk of fracture benefit most from HT.
Creative scientists take on recruitment challenge
4/4/17
2017 Creative Scientist Workshop: “Innovations in Recruitment to Clinical Trials,” March 14-15, 2017
CTSI Mentored Career Development Award goes to Jason Davies
4/3/17
The Clinical and Translational Science Institute (CTSI) announced the presentation of a new CTSI Mentored Career Development Award in March.
Clinical Research Office launches CTSI Research Round Table series
3/7/17
The University at Buffalo Clinical Research Office (CRO) and the Clinical and Translational Science Institute (CTSI) will begin hosting a bimonthly Research Round Table series at the end of March.
Building bridges a key element of Drug Development Core mission
3/7/17
The main objective of the University at Buffalo Clinical and Translational Science Institute (CTSI) Drug Development Core is to foster innovation in drug development and clinical therapeutics research.
Renowned influenza vaccine expert kicks off CTSI 2017 Seminar Series
2/17/17
An illustrious researcher in the field of infectious disease epidemiology was the guest speaker at the inaugural Clinical and Translational Science Institute 2017 Seminar Series on Feb. 10 in Farber Hall on UB’s South Campus. A standing-room-only crowd in the 105-seat lecture hall welcomed Arnold S. Monto, MD, to town for the seminar, co-sponsored by the UB School of Public Health and Health Professions and the CTSI.
2017 Creative Scientist Workshop
2/17/17
Discuss and develop novel approaches to clinical trials in a unique, collaborative environment.
CTSI scientists author widely read insecticide study
2/16/17
Common insecticides mimic melatonin, creating higher potential risk for diabetes and metabolic diseases
Community of Scholars Professional Development Series presents overview of Drug Development core
2/9/17
Role of the Drug Development Core in the UB Clinical and Translational Science Institute
Introducing the University at Buffalo Clinical and Translational Science Institute
2/3/17
UB-led consortium that earned prestigious National Institutes of Health grant moves into a new phase
Free Microsoft Word plug-in facilitates reproducible research in academic medical science
2/1/17
Reproducible research, in which statistical programming and documentation is sufficient so that others may replicate results and the research process, is gaining widespread practice in biostatistics and many other areas of science.
Pilot studies program continues to grow
1/24/17
In 2015-16, a total of $600,000 was provided to the Clinical and Translational Science Award (CTSA) Pilot Translational and Clinical Studies Program.
BTC researchers encouraged to apply for PCORI grants
1/17/17
The LOIs are due February 14. LOI templates, some reflecting new page limits, were made available on the PCORI website on January 17.
New i2b2 dashboard unveiled at CTSA Open House
12/29/16
Clinical research teams in the Buffalo Translational Consortium (BTC) have a powerful new tool for accessing the de-identified electronic health records (EHRs) of some 700,000 UBMD patients. (UBMD is the practice plan of UB’s Jacobs School of Medicine and Biomedical Sciences.) Created by UB’s Institute for Healthcare Informatics (IHI), with the support of the Clinical and Translational Science Award (CTSA), a new desktop dashboard connects investigators to the massive i2b2 (Informatics for Integrating Biology and the Bedside) database from the convenience of their own desktops.
More than a good idea, citing the CTSA is required by the NIH
12/22/16
All publications, press releases and other documents that result from the use of any University at Buffalo Clinical and Translational Science Award (CTSA) resources are required by the National Institutes of Health (NIH) to credit the CTSA
Hope for MS sufferers rides on development of new drug therapies
12/16/16
“Inducing Myelin Repair by Antagonism of Muscarinic Receptor Type-3”
Researchers focus efforts on ‘super bug’ weak point
12/15/16
“Development of High-Throughput Assay for Inhibitors of Aerobactin Synthesis”
Low-cost, portable biosensor system may boost early detection of lung cancer
12/15/16
“Highly Sensitive and Portable Surface Plasmon Resonance System for Lung Cancer Early Detection”
Investigating the roots of a poorly understood immune disease
12/15/16
“Analysis of the Source and Significance of IgM in Sjögren’s Syndrome”
Improving ovarian cancer diagnostics while advancing the state of metabonomics
12/15/16
“Multi-class modeling of metabonomics data for the detection of early stage ovarian cancer”