Environmental contamination by PFASs poses significant public health risks due to their persistent and toxic nature. Biodegradation of PFASs is slow and incomplete, often resulting in the formation of still-toxic by-products. This research proposes an innovative remediation approach combining catalytic hybrid nanomaterials with enriched microbial communities to efficiently and completely destroy PFASs without toxic by-product formation. Multifunctional nanohybrids will catalyze defluorination and oxidation of PFASs, converting them to more biodegradable forms. Enriched microbial consortia will degrade PFASs, with metagenomic tools identifying responsible microorganisms and their functional characteristics. By-products will be characterized using advanced techniques, informing the design of efficient nano-enhanced bioremediation systems for complete PFAS degradation.