Study the tiny molecular motors that cells use to produce force and motion in human cells.
This project is not being offered for the current term. Please check back next semester for updates.
To break symmetry, all cells polarize making one part of the cell structurally, functionally, or computationally different than another. Polarization requires a complex arrangement of active processes including the production of force to produce the cornucopia of cell shapes and structures found throughout life. In humans force is produced in part through tiny molecular motors that act upon the cytoskeleton. This project focuses on the human gene products of Myo9B and MYH9 which are both myosin motors that produce force and motion on the actin cytoskeleton. Disruption of the proteins deriving from these genes, results in multiple human disease of the gut including Celiac disease. This project involves working with a team of graduate and post graduate level trainees to study the function of these motors in human cells using state of the art light microscopy, cell biology and biochemistry.
Length of commitment | Longer than a semester; 6-9 months) |
Start time | Spring (January/February 2025) Summer (May/June 2025) |
In-person, remote, or hybrid? | In-Person Project (Can only function with in-person engagement) |
Level of collaboration | Small group project (2-3 students) |
Benefits | Stipend |
Who is eligible | Sophomores, Juniors and Seniors that have taken BCH403 course |
Andrew Lombardo
Assistant Professor
Biochemistry
Phone: (716) 881-8007
Email: atlombar@buffalo.edu
Once you begin the digital badge series, you will have access to all the necessary activities and instructions. Your mentor has indicated they would like you to also complete the specific preparation activities below. Please reference this when you get to Step 2 of the Preparation Phase.
Lombardo, Biochemistry, Force, Myosin, Actin, Jacobs School of Medicine and Biomedical Sciences