Ayesha Jannat: MN Fumes Exposure and the Quantification of Glutathione Ratio in Astrocytes and Microglia

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In this project, Ayesha studied the effects of manganese fumes on the brain and neurological disorders. Here is what Ayesha had to say about the experience:

What I Did:

"My research focused on understanding how exposure to manganese (Mn) fumes affects brain cells, specifically astrocytes and microglia, by measuring changes in their glutathione ratio, which is one of the key indicators of oxidative stress. Since excessive Mn exposure is linked to neurological disorders, our goal was to explore how it disrupts cellular balance, potentially leading to neurodegenerative conditions. One of the most impactful aspects of this project was its contribution to understanding environmental neurotoxicity. By identifying how Mn exposure alters oxidative stress in brain cells, this research could help inform future studies on neurological disease prevention and treatment."

What I Learned:

"Through my research project on "Mn fumes exposure and the quantification of the glutathione ratio in astrocytes/microglial cells", I gained invaluable hands-on experience in laboratory techniques, data analysis and problem solving. I also developed a deeper understanding of oxidative stress mechanisms and neurotoxicity. Additionally, I improved my ability to critically evaluate scientific literature, troubleshoot experimental challenges and adapt some methods to improve data accuracy. These all have strengthened my analytical thinking and research skills necessary for future professional program and career."