Paez Research Overview

Our research program focuses on brain development, studying the development of the oligodendroglial and astroglial cell lineages in the central nervous system in normal, mutant and transgenic mice. The primary focus in the laboratory is on ion channels that regulate specification, migration and differentiation of these glial cells. The oligodendrocyte generates CNS myelin, which is essential for normal nervous system function. Thus, investigating the regulatory and signaling mechanisms that control its differentiation and the production of myelin is relevant to our understanding of brain development and of adult pathologies such as multiple sclerosis. Astrocytes are the most abundant cell of the human brain. They perform many functions, including biochemical support of endothelial cells that form the blood brain barrier, provision of nutrients to the nervous tissue and a role in the repair and scarring process of the brain and spinal cord following traumatic injuries. Therefore, understanding the role of ion channels on astrocyte development and function could lead to novel approaches to intervene in neurodegenerative diseases and brain injuries in which inflammation and astrogliosis play a detrimental role.

Faculty and Staff

Dr. Pablo M. Paez

Associate Professor of Pharmacology & Toxicology

Dr. Pablo M. Paez is a Principal Investigator of the Institute for Myelin and Glia Exploration and Assistant Professor in Pharmacology and Toxicology in the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo...

photo of Dr. Pablo M. Paez.

Veronica Cheli

RESEARCH ASSISTANT PROFESSOR, NEUROLOGY; SENIOR RESEARCH SCIENTIST, Paez Lab

  • 2019-present: Research Assistant Professor, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, The State University of New York
  • 2013-present: Senior Research Scientist, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences University at Buffalo, The State University of New York
  • 2011-2012: Staff Research Associate, Intellectual and Developmental Disabilities Research Center David Geffen School of Medicine University of California at Los Angeles
  • 2006-2011: Postdoctoral Scholar, Department of Human Genetics, David Geffen School of Medicine University of California at Los Angeles
  • 2000-2006: Academic Tutor/Teaching Assistant, Laboratory of Neuroscience, Department of Cell Biology School of Pharmacy and Biochemistry University of Buenos Aires, Argentina.
  • 2000-2005: Research Assistant and Instructor, Laboratory of Neuroscience, Department of Cell Biology School of Pharmacy and Biochemistry University of Buenos Aires, Argentina.

 

photo of Veronica Cheli.

Diara Santiago Gonzalez

Postdoctoral Associate, Paez Lab

  • 2017 - present: Postdoctoral Associate at the University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Department of Pharmacology and Toxicology, Institute for Myelin and Glia Exploration.
  • 2012 - 2017: PhD Student at the University at Buffalo, NY, USA, Jacobs School of Medicine and Biomedical Sciences, Department of Pharmacology and Toxicology, Institute for Myelin and Glia Exploration.
  • 2008 - 2012: Bachelor Degree in Chemistry, University of Puerto Rico, Rio Piedras Campus.
photo of Diara Santiago Gonzalez.

Qiuchen Wan

Master Student, Paez Lab

  • 2018 – present: MS Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences. Research Technician, Paez Lab, Institute for Myelin and Glia Exploration, University at Buffalo.
  • 2016: Oversea Summer Exchange Program, University of California at San Diego.
  • 2014 – 2018: BS Marine Pharmacy, China Pharmaceutical University.

 

photo of Norma Zamora.

Past Members

photo of Tensing Lama.

Tensing Lama, Master student, College of Art and Sciences

photo of Rensheng Wan.

Rensheng Wan, Master Student, Pharmacology and Toxicology

photo of Vilma Spreuer.

Vilma Spreuer, Research Technician, Paez Lab

photo of Shaina Rosenblum.

Shaina Rosenblum, Master Student, Neuroscience

photo of Norma Zamora.

Norma Zamora, PhD Student, Department of Pharmacology and Toxicology