Basic research is based on a multi-disciplinary approach to understand how myelin is formed, how it is damaged in disease, and how it may be repaired. In particular, the Institute will study disease mechanisms of Krabbe Disease in order to formulate therapies. The Institute strives to generate information that will promote effective treatment strategies not only for children with leukodystrophies, but also patients with Multiple Sclerosis, stroke, neuropathies and other diseases in which myelin is damaged.

  • Feltri Laboratory
    We seek to understand how cell-cell and cell-extracellular matrix interactions contribute to cell shape and polarity within a developing tissue.
  • Paez Laboratory
    During the past five years Dr. Paez have found new and novel functions of voltage and store-operated Ca ++ channels as modulators of intracellular Ca ++ levels in oligodendrocytes.
  • Park Laboratory
    Our research goal is to understand the transcriptional regulatory network governing the differentiation of oligodendrocytes and central nervous system myelination.
  • Wrabetz Laboratory
    The Wrabetz Laboratory is interested in the molecular genetics of myelination, studied primarily in transgenic mice.
  • Lawrence Wrabetz archive
    Founding Director, Hunter James Kelly Research Insitute; Professor of Neurology and Biochemistry
  • M. Laura Feltri legacy page
    SUNY Distinguished Professor, Professor of Biochemistry and Neurology, Past Director, Institute for Myelin and Glia Exploration