Institute for Myelin and Glia Exploration Faculty: (front) Langan, Feltri, Paez; (back) Wrabetz, Park, Beirowski
Basic Science
Mission
To develop a multi-disciplinary approach to understand how myelin is formed, how axons and myelin are damaged in disease, and how they may be repaired.
Objectives
To study myelin formation as a source for strategies of myelin repair
To study consequences of myelin damage—common to all diseases of myelin—such as inflammation or neurodegeneration
To provide better cellular and animal models for identifying mechanisms of disease
To exploit models to perform preclinical studies of therapies
To translate the research of Myelin and Glia Exploration Institute into prognostic, diagnostic and treatment application
Clinical Science
Mission
To provide better diagnostic, prognostic and therapeutic options for Krabbe Leukodystrophy patients.
Objectives
To develop initiatives to maximize the success of the Newborn Screening program for Krabbe Disease
To increase understanding of various types of Krabbe Disease, determine which biochemical, genetic, and neurodiagnostic tests predict phenotype
To educate physicians about Krabbe Disease and Newborn Screening
To develop natural history studies, clinical evaluation and treatment protocols for Krabbe