Our Mission
Institute for Myelin and Glia Exploration Faculty: (front) Langan, Feltri, Paez; (back) Wrabetz, Park, Beirowski
Basic Science
Mission
To develop a multi-disciplinary approach to understand how myelin is formed, how axons and myelin are damaged in disease, and how they may be repaired.
Objectives
- To study myelin formation as a source for strategies of myelin repair
- To study consequences of myelin damage—common to all diseases of myelin—such as inflammation or neurodegeneration
- To provide better cellular and animal models for identifying mechanisms of disease
- To exploit models to perform preclinical studies of therapies
- To translate the research of Myelin and Glia Exploration Institute into prognostic, diagnostic and treatment application
Clinical Science
Mission
To provide better diagnostic, prognostic and therapeutic options for Krabbe Leukodystrophy patients.
Objectives
- To develop initiatives to maximize the success of the Newborn Screening program for Krabbe Disease
- To increase understanding of various types of Krabbe Disease, determine which biochemical, genetic, and neurodiagnostic tests predict phenotype
- To educate physicians about Krabbe Disease and Newborn Screening
- To develop natural history studies, clinical evaluation and treatment protocols for Krabbe