Have a faculty appointment as assistant professor (eligible for tenure) at the time of the award
Have a strong commitment to a research career and be able to commit 75% of effort to research and training related activities
Be a U.S. citizen or permanent resident of the United States
Have not previously received funding as principal investigator of a major federal research award (e.g. R01)
Meet the eligibility criteria for a subsequent individual NIH K award (those having received a K award or have a K submission under review are not eligible)