Proteomics & Bioanalysis Core (PBC) @ the NYS Center of Excellence in Bioinformatics and Life Sciences (CBLS)

Researcher putting fluid in a test tube.

Located on the Buffalo Niagara Medical Campus at the Center of Excellence in Bioinformatics and Life Sciences (CBLS), the Proteomics & Bioanalysis Core serves as a regional resource for UB and regional investigators, providing state-of-the art instrumentation and expertise in proteomics and biopharmaceutical analysis.

About Proteomics & Bioanalysis Core

PBC specializes in proteomics, liquid chromatography-mass spectrometry and bioinformatics. It operates as a collaborative core, developing analytical strategies that address significant bioanalytical challenges—advancing knowledge in a variety of applications. The final analytical strategies often represent combined developments in instrumentation, sample processing, and data analysis. The PBC services Fortune 500 companies, such as Merck and Johnson & Johnson. 

The facility has several main research foci:

  • Ultra-sensitive quantification of small-molecule analyses such as drugs, metabolites, and biomolecules;
  • Comprehensive protein expression profiling and differential proteome analysis;
  • Ultra-sensitive quantification of proteins/peptides.

The facility features highly sensitive mass spectrometers, including the Thermo Scientific™ Orbitrap Fusion™ Tribrid™ Mass Spectrometer with ETD fragmentation and high-performance liquid chromatography systems. The PBC also includes a well-equipped wet-lab devoted to cell culture, biochemistry experiments (for Western blotting, electrophoresis, ELISA, etc.), column packing, treatment of proteomic samples and preparation for quantitative analysis.

Participation and Eligibility

The PBC is available to UB’s scientific community, partner institutes, other SUNY schools, industrial clients and collaborators. There is an evaluation process.

For More Information

Smitha James.

Smitha James

Associate Director, Scientific Operations & Industry Engagement

NYS Center of Excel in Bioinformatics and Life Science

Phone: (716) 881-8940

Email: srjames@buffalo.edu