Peripheral Biomarkers of Cocaine Dependence and Relapse

Thompson | Straubinger | Qu
This project developed analytic methods to conduct large-scale analyses of brain peptides to (a) better understand how cocaine abuse changes brain activity and (b) identify changes of relapse vulnerability.

In this project, Dr. Thompson and colleagues studied the protein composition of plasma and brain tissue samples from animal models of cocaine dependence, withdrawal, and stress-induced relapse. Their goal was to identify biomarkers of cocaine history and/or vulnerability to stress-induced reinstatement of cocaine-induced behavior. Dr. Thompson’s colleagues for this Multiple Principal Investigator award include Drs. Robert Straubinger and Dr. Jun Qu, both of UB’s School of Pharmacy. Funded by a grant of $183,280 from NIDA, 2009-2012.