Prenatal Ethanol Exposure and Nitric Oxide Signaling in Serotonin Neurons

Researchers will study how prenatal alcohol exposure alters the function of the brain's serotonin system.

Dysfunction of the brain serotonin system plays is one of the major cause of psychiatric disorders associated with fetal alcohol spectrum disorder (FASD), yet how prenatal ethanol exposure alters the function of serotonin system, has remained a long-standing question in the field of FASD research. Using a translational animal model of FASD, the proposed studies seek to address this issue and elucidate the mechanisms and precise neuronal circuitries mediating the dysfunction of serotonin system in FASD. The outcome of this study will greatly enhance our understanding of the role of serotonin system in FASD and help the development of novel therapeutic strategies for FASD.

Principal Investigator
Samir Haj-Dahmane, PhD
Clinical and Research Institute on Addictions
Department of Pharmacology and Toxicology

Funding Agency
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Grant Number