Combatting Antimicrobial Resistance in the Environment

With a projected 10 million deaths per year, antimicrobial resistant pathogens are predicted to be the leading cause of death worldwide by 2050. Pharmaceutical development cannot keep pace with the problem. To combat these threats before they reach cities, hospitals, and homes, we work with international partners such as the icddr,b seeking out and deterring resilient pathogens in the farms, aquacultures, wastewaters, and other ecologies from which they spread.

What is Antimicrobial Resistance?

By Diana Aga

According to the WHO, Antimicrobial Resistance (AMR) is an increasingly serious threat to global public health that requires action across all government sectors and society. Without effective antibiotics, prevention and treatment of infections caused by bacteria, parasites, viruses and fungi and the success of major surgery and cancer chemotherapy would be compromised. Health care costs would increase as length of stay in normal and intensive care increases. The rise of antibiotic resistance is a global health crisis; it is an increasingly serious threat to global public health that requires action across all government sectors and society.

The emergence and spread of AMR outside hospitals can be exacerbated by various environmental factors such as the continuous discharge of antimicrobial drug residues, antibiotic resistance genes, and antibiotic resistant bacteria from hospital, municipal, and agricultural wastewaters. In addition, the widespread non-clinical use of antimicrobials in apple and pear orchards, aquaculture, and animal production can promote the development of AMR in commensal bacteria, which may later transfer antibiotic resistance genes to pathogenic bacteria that will eventually infect humans. To combat the spread of antibiotic resistant pathogens, the AMR Team will comprehensively investigate the environmental sources and drivers of AMR, and advance the methods of global AMR surveillance.

Articles and Reflections

“Antibiotic resistance is a global problem, and a lot of researchers are trying to fight it by creating new drugs...we are looking at the problem from a different angle: We are trying to prevent its spread.”

Diana Aga, Henry M. Woodburn Professor of Chemistry

Our Working Solutions

11/1/17
Laguna Bay, Phlippines, is the the largest lake in the Philippines surrounded by poultry and swine farms. 55% of smallholder farmers and 59% of commercial farms dump their untreated effluent into the lake. This water is a  source of tap water in nearby residential areas.
11/1/17
Residues of antimicrobial drugs and their metabolites, antibiotic resistance genes (ARGs), and antibiotic resistant bacteria (ARBs), are continuously introduced into the aquatic environment from hospital wastewater discharges and municipal wastewater treatment plant (WWTP) effluents. However, current literature lacks an understanding of the role of antibiotic resistance (AR) elements from the environment on the proliferation and dissemination of AR in a human population that is directly impacted by these wastewater-contaminated waters.

Our Team

Faculty Fellows

Diana Aga

Henry M. Woodburn Professor of Chemistry; Director of Graduate Studies

Department of Chemistry

611 Natural Sciences Complex

Phone: 716-645-4220

Email: dianaaga@buffalo.edu

Jared Aldstadt

Associate Professor

Department of Geography

117 Wilkeson Quad

Phone: 716-645-0481

Email: geojared@buffalo.edu

John Crane

Professor of Medicine; Adjunct Professor of Micro & Immunol. and of Pharmacol & Tox.

Department of Medicine

317 Biomedical Research Building

Phone: 716-829-2676

Email: jcrane@buffalo.edu

Shamim Islam

Clinical Assistant Professor

Pediatrics

Women and Childrenā€˜s Hospital of Buffalo, Division of Infectious Diseases, 219 Bryant Street

Phone: 716-878-7290

Email: shamimis@buffalo.edu

Lauren Sassoubre

Assistant Professor

Civil, Structural and Environmental Engineering

230 Jarvis Hall

Phone: 716-645-1810

Email: lsassoub@buffalo.edu

Gail Willsky

Associate Professor

Biochemistry

140 Farber Hall

Phone: 716-829-2969

Email: gwillsky@buffalo.edu