The Center of Excellence for Document Analysis and Recognition (CEDAR)
CEDAR is internationally renowned for its pioneering research in handwriting recognition and delivering field installed solutions in the US, UK, and Australia. Research spans the areas of pattern recognition, machine learning, data mining, information retrieval, and computational linguistics. Generating $65M in funding since its inception, CEDAR has made several contributions with worldwide impact, including the first automation of the processing of handwritten addresses by the Internal Revenue Service, United States Postal Service, UK Royal Mail and Australia Post.

The Center for Unified Biometrics and Sensors (CUBS)
The focus of the research at the Center for Unified Biometrics and Sensors (CUBS) is the development of end-to-end biometric systems that integrate user interface technologies, informatics, sensing materials and technologies, and electronic devices. These applications range from human health monitoring systems to cyber security, and access and control. CUBS has expertise in combining multiple biometrics to provide secure user authentication techniques for the pervasive computer systems of the future. Several faculty members from departments across three schools are involved in various biometrics and sensors projects. CUBS has received over $5.0M in funding from federal agencies and industry over the last four years.

National Center for Geographic Information and Analysis (NCGIA)
The University at Buffalo has been prominent in geographic information science (GIS) research and training since the mid 1970s, and is home to one of the three National Center for Geographic Information and Analysis (NCGIA) sites. The NCGIA is an independent research consortium whose primary mandate is to conduct basic research in geographic information science and its related technology. NCGIA-Buffalo also coordinates the University’s participation in the University Consortium for Geographic Information Science (UCGIS), and in the New York State GIS Coordinating Committee. NCGIA-Buffalo currently has 24 official members distributed among nine departments in four schools. The UB Geographic Information Science community is even broader than that, involving nearly 60 UB faculty in over 20 departments or units. 

Center of Excellence in Information Assurance Education (CEISARE)
Over 15 faculty members from four departments actively collaborate to advance computing methodologies that protect information systems by ensuring availability, integrity, authentication, confidentiality, and non-repudiation. Research in this area is channeled through the recently formed NSA Center of Excellence in Information Assurance Education (CEISARE). The center leads several projects in applications of formal specifications and verification methods to a variety of problems in security. These include intrusion detection, insider threat mitigation, digital piracy, vulnerability analysis and mobile code security. CEISARE's focus is on designing robust, fault-tolerant and secure systems for e-commerce, grid computing and wireless networks.

The Center for Multisource Information Fusion (CMIF)
The Center for Multisource Information Fusion (CMIF), with $20 million dollars of funded programs since its inception, is focused on several information fusion activities. A sampling of recent projects sponsored by various federal agencies include: a connectionist approach to multi-attribute decision making, robust surveillance through adaptive management, distributed target tracking, cognitive modeling of human intentionality, and mammography.

Center for Computational Research (CCR)
The Center for Computational Research (CCR)  is among the leading university-based high-performance computing facilities worldwide. Over 60 faculty members from 25 departments at UB participate in various CS projects. The work done at CCR can be organized under three broad categories: (i) life sciences, (ii) physical sciences, and (iii) engineering. Since its inception, CCR and its staff have generated $20M in external funding and enabled $160M in external funding and $150M in in-kind donations.

The Center for Architecture and Situated Technologies (CAST)
CAST is devoted to work on the evolving and growing implications of new technologies within the built environment: social, political, ecological, and material. Our various research efforts address the impact of mobile and embedded computing, wireless networks, responsive systems and cybernetics on architecture and the city today. We consider issues like context, embodied interaction and performance as important, rapidly evolving characteristics to contemporary architecture and the city. Our Center’s research, pedagogy, design work and discourse are unique as a single group within a major research university, devoted to methodically addressing these emerging issues.

The New York State Center for Engineering Design and Industrial Innovation (NYSCEDII)
NYSCEDII serves as an important resource for the sustenance and growth of the industrial base in Western New York. By focusing on the front-end high technology, simulation, and information intensive design of complex engineered products and advanced transportation systems, NYSCEDII develops technologies and provides services that complement other economic development and training activities in the regionas well as the state. NYSCEDII's activities speak directly to regional needs.

The New York State Center of Excellence in Bioinformatics & Life Sciences (COE)
The COE in Bioinformatics and Life Sciences is deeply involved in a number of collaborative efforts with industry, government and researchers around the world. Formed in 2002 as part of more than $200 million dollars in investment from state, federal, industry and philanthropic sources to create a hub of life sciences expertise and innovation in Upstate New York, the COE's work is aimed at improving the health and well-being of the population.