Published March 27, 2013
Virginia Havel, a PhD student in microbiology
and immunology, has received an American Heart
Association Founders Affiliate predoctoral fellowship designed
to help students initiate careers in cardiovascular and stroke
The two-year, $44,000 fellowship will help fund research that may identify potential therapeutic targets for infections caused by a pathogenic fungus that causes more than 600,000 deaths a year worldwide.
The fungus, Cryptococcus neoformans, is a contributing factor to
mortality in organ transplant patients, such as those receiving
heart or lung transplants.
Havel is investigating mRNA degradation, a mechanism C. neoformans uses to adapt to the temperature of its host.
The fungus’ ability to survive in humans is severely compromised when factors involved in the degradation of its mRNA are mutated.