Published January 24, 2013
Jerome A. Roth, PhD, professor of pharmacology and toxicology, will use a four-year, $2 million grant from the National Institute for Occupational Safety and Health to study hearing loss resulting from long-term exposure to manganese and noise.
The study has important ramifications for workers exposed to manganese, especially welders.
Welding rods contain high concentrations of manganese, which is
released in fumes during the process of welding. Prolonged exposure
to high atmospheric levels of manganese causes neurological
symptoms similar to those in Parkinson’s disease as well as
hearing impairment, according to epidemiological studies and case
In vitro, manganese is toxic to auditory nerve fibers as well as spiral ganglion neurons and cochlear hair cells.
In 2011, Roth and his colleagues published a study in Neurotoxicology showing for the first time that low levels of manganese initially damage neurons and sensory hair cells in the inner ears of rats.
Roth’s study seeks to understand the mechanism for manganese-induced auditory loss, with the ultimate goal of finding new treatments that could prevent the condition.
He will assess the degree of hearing impairment and histopathological damage in rats resulting from various levels of manganese alone, noise alone and manganese combined with noise. He will also compare and evaluate resulting tissue damage and compare this to manganese levels in the separate components of the inner ear.
“We hypothesize that concurrent exposure to high levels of
continuous noise will exacerbate hearing impairment and damage to
the inner ear induced by manganese,” Roth says.
UB collaborators on the project include, from the Department of Communicative Disorders and Sciences:
from the Department of Chemistry: