Published April 26, 2013
For the second year, the UB Clinical and Translational
Research Center (CTRC) showcased award-winning studies and
technologies developed by UB researchers and collaborators.
Six projects were presented April 12 during the 2013 Clinical and Translational Research Colloquium.
These interdisciplinary projects show promise to translate quickly from the research stage to clinical use as improved treatments or medical procedures.
Each received a grant from the center's Translational Pilot Studies Program in 2012. The projects were selected from among 44 applications based on their potential to leverage major external funding.
"The colloquium was a great success, attracting more than 100
researchers and trainees from throughout UB and Roswell Park
Comprehensive Cancer Center," says Timothy
F. Murphy, MD, senior associate dean for clinical and
translational research and SUNY Distinguished Professor of medicine.
"It is exciting to see the high caliber of research supported by
the UB CTRC Translational Pilot Studies Program," he adds. "The
work presented has enormous potential to advance translational
science and will undoubtedly lead to larger extramural funding to
The projects are briefly described below.
The research team has developed a multifunctional optical imaging probe―a much-improved method for diagnosing skin lesions that occur in graft versus host disease.
This common and potentially serious disorder occurs in patients who have had bone marrow and stem cell transplants.
This dermatology research team investigated the use of
state–of-the-art proteomics methods, or protein studies,
to understand the cause of pemphigus vulgaris, an autoimmune
disease of the skin.
The researchers developed novel, sophisticated methods to identify the triggers of the autoimmune response, providing important new data that can lead to better treatment.
Their novel autoantigen arrays will aid the discovery of biomarkers for the disease.
A complication of a common form of breast cancer therapy is
damage to the heart. In an intriguing example of personalized
medicine, these researchers found that patients with a particular
genetic marker (present in about 40 percent of the population) are
far more susceptible to heart damage from this treatment compared
to people who lack the marker.
They studied the carbonyl reductase 3 genotype and its link to cardiomyopathy.
With further testing, this observation could lead to a powerful new individualized therapy for breast cancer that results in improved outcomes.
In a look into the future of antibiotic therapy, this research
team is testing photodynamic therapy, now used to treat some
cancers, as a novel antibiotic therapy for bacterial
The approach has great potential, particularly in treating infections caused by biofilms, which are bacteria encased in a thick material that resist conventional antibiotics.
This research team is working to better understand how a
cancerous tumor resists the human immune system, an important first
step in the quest to develop effective cancer vaccines.
Using sophisticated methods, the team is studying the tumor microenvironment to gain knowledge about these immune effects. This work has the potential to lead to novel ways to overcome the suppression of the immune system, thus enhancing the effectiveness of cancer vaccines.
Using state-of-the-art tissue engineering, these researchers are
developing grafts that surgeons can use to bypass blocked blood
vessels at many sites.
This novel approach is a huge improvement over current methods that rely largely on surgically “harvesting” veins from other sites.
The grants were funded through contributions totaling $200,000
from the following:
An interdisciplinary, 14-member Pilot Studies Oversight Committee selected the winning projects, following an initial round of peer review coordinated by Kenneth Tramposch, PhD, associate vice president for research.
The committee was co-chaired by Leonard H. Epstein, PhD, SUNY Distinguished Professor of pediatrics, and Steven J. Fliesler, PhD, Meyer H. Riwchun Endowed Chair Professor of ophthalmology, professor of biochemistry and research health scientist at the Buffalo VA Medical Center.