Published October 27, 2017
One of the main goals of UB’s Clinical and Translational Science Institute (CTSI) is to advance clinical and translational research that will improve the health and well-being of people living in Western New York, with a special emphasis on reducing the health disparities experienced by many in our community, including underrepresented minority groups and the poor.
The CTSI also seeks to encourage the kind of creative team science that reaches across disciplinary and institutional boundaries, and is most likely to produce paradigm-shifting breakthroughs.
Investigators from all eight research teams who received CTSI Translational Pilot Studies awards in the 2015-16 program year presented updates to the UB community on the results of their research at the annual Clinical and Translational Pilot Studies Research Colloquium, which was held October 12 in the Clinical and Translational Research Center (CTRC).
Grantees from the 2016-17 funding cycle also were on hand to present digital posters of their work-in-progress, the outcomes of which will be showcased at next year’s research colloquium.
From a clinical trial that tested an improved method of reducing maternal smoking to a radical new approach to preventing bacterial infections on metallic implants, research projects supported by the CTSI Translational Pilot Studies Program help to advance clinical and translational science on multiple fronts.
"Among the goals of our program is a commitment to support research that has the greatest likelihood of gaining additional, substantive extramural funding, particularly from the NIH, NSF, and other federal agencies,” said Steven J. Fliesler, PhD, co-director of the CTSI's Translational Pilot Studies Program, a UB Distinguished Professor and Meyer H. Riwchun Endowed Chair Professor of Ophthalmology in the Jacobs School of Medicine and Biomedical Sciences.
“We provide support for innovative studies in clinical and translational research that are directly relevant to the themes and priorities of our Clinical and Translational Science Award (CTSA), especially those focused on developing new methods and technologies to solve important clinical and translational research problems, and those that will foster cross-disciplinary collaborations and mentoring relationships," said Fliesler.
Mark Ehrensberger, PhD, assistant professor of biomedical engineering in the School of Engineering and Applied Sciences and the Jacobs School of Medicine and Biomedical Sciences, presented results of his pilot study, titled A Novel Electrical Stimulation Technology Changing the Paradigm for the Treatment of Orthopedic-related Infections. Ehrensberger described how the CTSI pilot study support allowed the research to advance to the next stage when it appeared no one else would underwrite it.
This work led to a multidisciplinary, two-year, $1.1 million Office of Naval Research grant to determine whether electrical stimulation, combined with a regimen of antibiotics, can treat or prevent the development of bacterial biofilms on metallic implants. Biofilms are colonies of harmful bacteria which coat metallic implants and are frustratingly difficult to eradicate.
The current standard of care for chronic implant infections involves surgical replacement of the infected hardware. In addition to the toll it takes on the patient, this method carries a heavy price tag.
Qiaoqiang Gan, PhD, associate professor in the Department of Electrical Engineering, School of Engineering and Applied Sciences, presented Highly Sensitive and Portable Surface Plasmon Resonance System for Lung Cancer Early Detection, his pilot study that was instrumental in helping to land a $1 million National Science Foundation (NSF) grant announced in September.
In collaboration with Dr. Yun Wu, PhD, assistant professor from the Department of Biomedical Engineering, Gan and Wu’s pilot study data provided proof-of-concept that a biosensor to detect lung cancer developed by the multidisciplinary team was at least as accurate, if not more accurate, than the current industry standard, but is also capable of being miniaturized to the point that it can be implanted under a patient’s skin.
“Our preliminary results were used in the application for this NSF grant,” said Gan, “although the proposal contains many other elements which go beyond our CTSI seed project.” The team working on development of the sensor includes UB engineers working with Intel Corp. and Garwood Medical Devices.
The next phase of the research, headed up by Josep Jornet, PhD, assistant professor of electrical engineering in the School of Engineering and Applied Sciences and the grant’s principal investigator, will seek to determine whether the miniature sensor can be connected via cellphone to a doctor’s office, allowing patients living in remote locations to monitor themselves.
Xiaozhong Wen, MD, PhD, a research assistant professor in the Division of Behavioral Medicine, UB Department of Pediatrics specializing in maternal and child health, enrolled 48 pregnant women who smoke in Pilot Study on Pediatric Obesity Prevention by Maternal Smoking Cessation in Pregnancy and Lactation, a clinical trial with two aims: first, to test an innovative method of smoking cessation in pregnancy and lactation and, second, to try to reduce the risk of childhood obesity due to maternal smoking.
Although children born of women who smoke during pregnancy often have low birth weight, paradoxically, they quickly catch up to their peers born to non-smoking mothers and often surpass them in weight gain. In fact, maternal smoking during pregnancy is one of the best predictors of pediatric obesity, which can be the forerunner of many other health problems such as type 2 diabetes and cardiovascular disease.
By far, most women who smoke during pregnancy come from socioeconomically disadvantaged backgrounds. Eighty-six percent of the women in Wen’s study were recruited from two of the City of Buffalo’s chronically underserved neighborhoods: 58 percent from the city’s East Side and 14 percent from the West Side. About 70 percent of the women in Wen’s program were African American, Hispanic or Native American. More than 60 percent of the women were single and more than 70 percent unemployed. About 80 percent had a high school diploma or lower level of education.
Not only does Wen’s diverse cohort of patients show that it’s possible to sign volunteers from populations that are traditionally difficult to recruit, results of the study also demonstrate how participants in clinical studies and their families who are experiencing health disparities can reap tangible health benefits through their participation.
Most of the participants (63 percent) in Wen’s study were able to stop smoking successfully during pregnancy, which was found to significantly improve their baby’s birth weight. Early results also show that maternal quitting smoking cessation during pregnancy seems to prevent the kind of rapid infant weight gain which is a risk factor for later obesity.
Andrew Gulick, PhD, from the Hauptman-Woodward Medical Research Institute (HWI) and UB’s Department of Structural Biology, presented Development of High-throughput Assay for Inhibitors of Aerobactin Synthesis. Gulick led a multi-institutional team of researchers from UB’s Jacobs School of Medicine and Biomedical Sciences and HWI on a novel project which targets a hypervirulent strain of the bacterium Klebsiella pneumonia, which causes outbreaks in hospitals and long-term care facilities, and which is also demonstrating increasing antimicrobial resistance, making it a genuine double-threat “super bug.”
The team’s approach, essentially, is to starve the bacteria of the iron it requires at a critical phase of its life cycle. Data collected in the pilot phase helped the team win a National Institutes of Health (NIH) Research Project Grant Program RO1 grant.
Jill Kramer, DDS, PhD, of UB’s Department of Oral Biology, School of Dental Medicine, is the principal investigator on Analysis of the Source and Significance of IgM in Sjögren’s Syndrome. Sjögren’s syndrome (SS) is an autoimmune disease characterized by dry eyes and a dry mouth. Kramer’s team is seeking to determine the role that a certain class of autoantibodies (IgM) plays in the course of the disease, since it is not currently known whether IgM is primarily pathogenic or protective in SS.
Fraser Sim, PhD, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, was the principal investigator on Inducing Myelin Repair by Antagonism of Muscarinic Receptor Type-3, a pilot study looking to identify a potential new site for future drug development for treating multiple sclerosis (MS) and other serious neurological disorders. Rates of MS in Western New York are twice the national average, according to the National MS Society, and Sim’s innovative approach could one day provide relief to the more than 3,000 people in the region suffering from this debilitating disease.
Thomas Szyperski, PhD, a UB distinguished professor in the College of Arts and Sciences’ Chemistry Department, presented Multi-class Modeling of Metabonomics Data for the Detection of Early Stage Ovarian Cancer, a cross-institutional, interdisciplinary project for the screening of high-risk Epithelial Ovarian Cancer (EOC) populations.
Ovarian cancers often escape detection until too late due to the absence of symptoms and effective tests. The approach established in the pilot study is to generate profiles that discriminate between blood samples from healthy women and those from women with benign or malignant tumors.
In addition to UB’s Department of Chemistry in the School of Arts and Sciences, the team includes members from the Department of Biostatistics in the School of Public Health and Health Professions, and Roswell Park Cancer Institute’s Department of Gynecologic Oncology.
Xuefeng Ren, MD, PhD, in the Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, presented Inheritable Epigenetic (DNA methylation) Biomarkers and Actions of Arsenic Exposure in its Carcinogenic Activity.
Opening remarks of the 2017 Research Colloquium were delivered by Timothy F. Murphy, MD, SUNY Distinguished Professor and director of the CTSI. Co-directors of the Translational Pilot Studies Program Steven J. Fliesler, PhD, and Brahm H. Segal, MD, provided an introduction to the program, and Fliesler closed out the session with a presentation, “Program Overview and Tips for Success in Obtaining CTSA Pilot Studies Funding.”
Look for the next request for proposals (RFP) in the summer of 2018.
The CTSI Translational Pilot Studies Program is supported by the NIH and partners in the Buffalo Translational Consortium: