CTSI Translational Pilot Studies Program awards 13 new grants for 2022

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Pictured, in alphabetical order, are the principal investigators and co-investigators for projects awarded 2022 CTSI Translational Pilot Studies Program funding.

Published January 5, 2022

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Brahm Segal.
“In addition to developing new methods and technologies to impact and improve public health, these innovative projects will foster cross-disciplinary collaborations and mentoring relationships.”

The University at Buffalo’s Clinical and Translational Science Institute (CTSI) has awarded 13 new grants to support innovative translational research projects in Western New York. The CTSI Translational Pilot Studies Program provides seed money to investigators to assist them in developing promising new technologies and therapeutics from the conceptual stage to clinical studies.

“The 13 projects awarded pilot studies grants for 2022 address significant translational research questions,” says CTSI Pilot Studies Program Director Brahm Segal, MD, Chair, Department of Internal Medicine, Chief, Division of Infectious Diseases, and Professor of Oncology, Roswell Park Comprehensive Cancer Center. “In addition to developing new methods and technologies to impact and improve public health, these innovative projects will foster cross-disciplinary collaborations and mentoring relationships.”

Recipients of 2022 CTSI Translational Pilot Studies Program awards are:

Hijacking Therapeutic Resistance in High-risk Localized and Advanced Prostate Cancer

Principal Investigator: Remi Adelaiye-Ogala, PhD, Jacobs School of Medicine and Biomedical Sciences

Co-Investigators: Roberto Pili, MD, Jacobs School of Medicine and Biomedical Sciences; John Tomaszewski, MD, Jacobs School of Medicine and Biomedical Sciences

Weight Management Program for Patients With First Episode Psychosis

Principal Investigator: Daniel Antonius, PhD, Jacobs School of Medicine and Biomedical Sciences

Co-Investigators: Leonard Epstein, PhD, Jacobs School of Medicine and Biomedical Sciences; Kenneth Leonard, PhD, Jacobs School of Medicine and Biomedical Sciences, and Director, Clinical and Research Institute on Addictions; Zhanna Elberg, MD, Jacobs School of Medicine and Biomedical Sciences

Epigenetic and Cytokine Biomarkers During Recovery From Sport-Related Concussion

Principal Investigator: Praveen Arany, DDS, PhD, School of Dental Medicine

Co-Investigators: John Leddy, MD, Jacobs School of Medicine and Biomedical Sciences; Barry Willer, PhD, Jacobs School of Medicine and Biomedical Sciences; Mohammad Nadir Haider, MD, PhD, Jacobs School of Medicine and Biomedical Sciences; Haley Chizuk, graduate student, School of Public Health and Health Professions

Antimicrobial Photodynamic Therapy (aPDT) for Eradication of Microbial Biofilms on Urinary Catheters

Principal Investigator: Chelsie Armbruster, PhD, Jacobs School of Medicine and Biomedical Sciences

Co-Investigators: Anthony Campagnari, PhD, Jacobs School of Medicine and Biomedical Sciences; Nicole Luke-Marshall, PhD, Jacobs School of Medicine and Biomedical Sciences; Teresa Danforth, MD, Jacobs School of Medicine and Biomedical Sciences

Point-of-care Metagenomics for Rapid Pathogen Identification in Critically-ill Children With Sepsis

Principal Investigators: Patricia Diaz, DDS, PhD, School of Dental Medicine; Anil Kumar Swayampakula, MD, MPH, Jacobs School of Medicine and Biomedical Sciences

Co-Investigators: Michael Buck, PhD, Jacobs School of Medicine and Biomedical Sciences; Jaroslaw Zola, PhD, School of Engineering and Applied Sciences; Jeffrey Miecznikowski, PhD, School of Public Health and Health Professions; Jeremy Killion, MD, Jacobs School of Medicine and Biomedical Sciences  

Preserving Lean Body Mass During Weight Loss in Elderly Obese Patients With GLP-1 Receptor Agonist Treatment

Principal Investigator: Husam Ghanim, PhD, Jacobs School of Medicine and Biomedical Sciences

Co-Investigators: Paresh Dandona, MD, PhD, Jacobs School of Medicine and Biomedical Sciences; Bruce Troen, MD, Jacobs School of Medicine and Biomedical Sciences; Manav Batra, MD, Jacobs School of Medicine and Biomedical Sciences; Kenneth Seldeen, PhD, Jacobs School of Medicine and Biomedical Sciences

Microbiome Influence on Oral Cavity Cancer Regional Metastasis

Principal Investigator: Vishal Gupta, MD, Roswell Park Comprehensive Cancer Center

Co-Investigators: Patricia Diaz, DDS, PhD, School of Dental Medicine; Keith Kirkwood, DDS, PhD, School of Dental Medicine; Wesley Hicks, Jr, DDS, MD, Roswell Park Comprehensive Cancer Center; Subin Surendran, PhD, Roswell Park Comprehensive Cancer Center; Lu Li, PhD, School of Dental Medicine

Novel Role of Heparan Sulfate in Regulating Cell Signaling in Palatogenesis and Cleft Palate Pathogenesis

Principal Investigator: Hyuk-Jae Edward Kwon, DDS, PhD, School of Dental Medicine 

Co-Investigators: Ding Xu, PhD, School of Dental Medicine; Yungki Park, PhD, Jacobs School of Medicine and Biomedical Sciences

Multisite Analysis of the Microbiome in Aging Postmenopausal Women

Principal Investigator: Michael LaMonte, PhD, School of Public Health and Health Professions

Co-Investigators: Susan Baker, MD, PhD, Jacobs School of Medicine and Biomedical Sciences; Vanessa Barnabei, MD, PhD, Jacobs School of Medicine and Biomedical Sciences; Manoj Mammen, MD, MS, Jacobs School of Medicine and Biomedical Sciences; Patricia Diaz, DDS, PhD, School of Dental Medicine; Lu Li, PhD, School of Dental Medicine; Yijun Sun, PhD, Jacobs School of Medicine and Biomedical Sciences; Christopher Andrews, PhD, School of Public Health and Health Professions; Ahmed Soliman, PharmD, School of Public Health and Health Professions; Jean Wactawski-Wende, PhD, School of Public Health and Health Professions

A SARS-Cov-2 Virus Like Particle (VLP) Technology Platform

Principal Investigator: Sriram Neelamegham, PhD, School of Engineering and Applied Sciences

Co-Investigators: Jonathan Lovell, PhD, Jacobs School of Medicine and Biomedical Sciences; Brian Weil, PhD, Jacobs School of Medicine and Biomedical Sciences

Using the Social Ecological Model to Facilitate Pre-Exposure Prophylaxis (PrEP) Utilization for the Prevention of HIV Infection: Understanding Patient and Provider Perspectives to Reduce Health Inequities

Principal Investigator: Sarahmona Przybyla, PhD, MPH, School of Public Health and Health Professions

Co-Investigators: Gene Morse, PharmD, School of Pharmacy and Pharmaceutical Sciences; Amy Hequembourg, PhD, School of Nursing

Precision Dosing Strategies for Vancomycin and Aminoglycosides: Improving the Care of Patients in Buffalo Through Therapeutic Individualization

Principal Investigator: Nicholas Smith, PharmD, PhD, School of Pharmacy and Pharmaceutical Sciences

Co-Investigators: Brian Tsuji, PharmD, School of Pharmacy and Pharmaceutical Sciences; Alan Lesse, MD, Jacobs School of Medicine and Biomedical Sciences; Raymond Cha, PharmD, School of Pharmacy and Pharmaceutical Sciences; Kari Mergenhagen, PharmD, School of Pharmacy and Pharmaceutical Sciences

Piloting an Evidence-based Mobile Mindfulness Practice to Support Self-Management Among Underserved and Racial Minority Adults With Pulmonary Hypertension

Principal Investigator: Tania Von Visger, PhD, Jacobs School of Medicine and Biomedical Sciences

Co-Investigators: Yu-Ping Chang, PhD, RN, School of Nursing; Alan Hunt, MS, School of Engineering and Applied Sciences; Chin-Shang Li, PhD, School of Nursing;  William Gibbons, MD, Jacobs School of Medicine and Biomedical Sciences

Funding for the CTSI Translational Science Pilot Studies Program is provided by: UB’s Office of the Provost, Office of the Vice President for Research and Economic Development, and Office of the Vice President for Health Sciences; Roswell Park Comprehensive Cancer Center; and the deans of UB’s Jacobs School of Medicine and Biomedical Sciences, School of Dental Medicine, School of Pharmacy and Pharmaceutical Sciences, School of Engineering and Applied Sciences, School of Public Health and Health Professions, and School of Nursing.