Sriram Neelamegham Laboratory

The Sriram Neelamegham Laboratory investigates the fields of Molecular and Cellular Bioengineering, Systems Glycobiology and Thrombosis & Hemostasis. Researchers are interested in applying quantitative experimental and computational techniques to discover new mechanisms that control the cell adhesion properties of blood leukocytes and platelets during human inflammatory and thrombotic disorders. Projects in this laboratory assess the roles of fluid/hydrodynamic forces, biochemical reaction networks and cell adhesion molecule binding properties on blood cell adhesion mechanics during inflammation, thrombosis, hemostasis and cancer. The researchers' long-term goal is to apply their knowledge of the regulatory pathways to identify new targets for drug development.