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Wayne Schultz

L. Wayne Schultz, Ph.D.

Hauptman-Woodward Institute, Senior Research Scientist
Department of Structural Biology, Assistant Professor

Specialty/Research Focus

Structural characterization of proteins from SARS coronavirus & mouse hepatitis virus; Identification & characterization of virus; Host protein interactions involved in animal to human transmission; Enzymatic mechanism of light emission & pH-regulation of luciferases from marine dinoflagellates; Sensing cellular oxygen levels by prolyl-hyroxylases.


  1. Influenza A polymerase subunit PB2 possesses overlapping binding sites for polymerase subunit PB1 and human MAVS proteins. Patel D, Schultz LW, Umland TC. Virus Res. 2013 Mar;172(1-2):75-80. doi: 10.1016/j.virusres.2012.12.003. Epub 2012 Dec 12. PMID: 23246644 [PubMed - in process] Related citations Select item 229119672.
  2. In vivo-validated essential genes identified in Acinetobacter baumannii by using human ascites overlap poorly with essential genes detected on laboratory media. Umland TC, Schultz LW, MacDonald U, Beanan JM, Olson R, Russo TA. MBio. 2012 Aug 31;3(4). doi:pii: e00113-12. 10.1128/mBio.00113-12. Print 2012. PMID: 22911967 [PubMed - indexed for MEDLINE]  Free PMC Article Related citations Select item 171879873.
  3. Expression, purification and characterization of recombinant severe acute respiratory syndrome coronavirus non-structural protein 1. Brucz K, Miknis ZJ, Schultz LW, Umland TC. Protein Expr Purif. 2007 Apr;52(2):249-57. Epub 2006 Nov 14. PMID: 17187987 [PubMed - indexed for MEDLINE]  Free PMC Article Related citations Select item 156650924.
  4. Crystal structure of a pH-regulated luciferase catalyzing the bioluminescent oxidation of an open tetrapyrrole. Schultz LW, Liu L, Cegielski M, Hastings JW. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1378-83. Epub 2005 Jan 21. PMID: 15665092 [PubMed - indexed for MEDLINE] Free PMC Article Related citations Select item 126578055.
  5. Characterization and crystallization of active domains of a novel luciferase from a marine dinoflagellate. Liu L, Im H, Cegielski M, LeMagueres P, Schultz LW, Krause KL, Hastings JW. Acta Crystallogr D Biol Crystallogr. 2003 Apr;59(Pt 4):761-4. Epub 2003 Mar 25. PMID: 12657805 [PubMed - indexed for MEDLINE] Related citations Select item 113059106.
  6. Contribution of the active site histidine residues of ribonuclease A to nucleic acid binding. Park C, Schultz LWRaines RT. Biochemistry. 2001 Apr 24;40(16):4949-56. PMID: 11305910 [PubMed - indexed for MEDLINE] Related citations Select item 110874027.
  7. Excavating an active site: the nucleobase specificity of ribonuclease A. Kelemen BR, Schultz LW, Sweeney RY, Raines RT. Biochemistry. 2000 Nov 28;39(47):14487-94. PMID: 11087402 [PubMed - indexed for MEDLINE] Related citations Select item 104894488.
  8. The CXXC motif: crystal structure of an active-site variant of Escherichia coli thioredoxin. Schultz LW, Chivers PT, Raines RT. Acta Crystallogr D Biol Crystallogr. 1999 Sep;55(Pt 9):1533-8. PMID: 10489448 [PubMed - indexed for MEDLINE] Related citations Select item 100483379.
  9. Variants of ribonuclease inhibitor that resist oxidation. Kim BM, Schultz LWRaines RT. Protein Sci. 1999 Feb;8(2):430-4. PMID: 10048337 [PubMed - indexed for MEDLINE] Free PMC Article Related citations Select item 987161810.
  10. Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12. Schultz LWClardy J. Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6. PMID: 9871618 [PubMed - indexed for MEDLINE] Related citations