The basic research conducted at the HJKRI is based on a multi-disciplinary approach to understand how myelin is formed, how it is damaged in disease, and how it may be repaired. Myelin diseases cause neurological problems by interfering with neuronal and axon function, so an important focus of HJKRI is to understand, prevent and reverse axonal degeneration. We use a variety of state-of-the art approaches that include genetic models, bioinformatics, primary cultures of neuronal and glial cells form patients and animal models, neurophysiology and live imaging.
