Infections by the pathogenic fungus Cryptococcus neoformans cause hundreds of thousands of deaths per year in the context of HIV infection in resource-poor areas of the world. Existing drugs are ineffective and access is limited. Our interests lie in strategies to augment the activity of existing antifungal drugs.
Synergy has been reported between Amphotericin B and 5-fluorocytosine.The mechanism of this synergy is unknown. By investigating the mechanism of synergy, we can design strategies to identify compounds that exploit maximally that mechanism of synergy.