How Signal Transduction Pathways Regulate Morphogenetic Responses

picture of candida albicans, fungal yeast, round and white.

Seeking students interested in understanding how signal transduction pathways regulate morphogenetic responses as relevant to human health, cancer and other diseases.

Project description

Our lab is interested in understanding how signal transduction pathways regulate morphogenetic responses. We study MAP kinase pathways in fungal species including the model genetic system budding yeast and human pathogen C. albicans. One focus of the lab is to understand how the polarity Rho-type GTPase Cdc42 is activated in the context of a specific MAP kinase pathway. Cdc42 and other proteins can function in multiple pathways. This is part of a general problem surrounding signaling pathways that control specific processes through networks of common or shared factors. How a specific output results from the activation of a common module is not clear and is a problem addressed by our lab. Understanding "signaling specificity" is relevant to human health because cross talk between pathways can lead to cancer and other diseases.

Project outcome

The specific outcomes of this project will be identified by the faculty mentor at the beginning of your collaboration. 

Project details

Timing, eligibility and other details
Length of commitment To be determined by student/mentor
Start time Fall, Spring, Summer
In-person, remote, or hybrid?
Level of collaboration To be determined by student/mentor
Benefits Academic Credit, Work Study
Who is eligible A/B average; hard working, self-motivated
Goldwater and the National Science Foundation

Students participating in this project might be interested in and eligible for the Goldwater Scholarship and the National Science Foundation Graduate Research Fellowship. Connect with the Office of Fellowships and Scholarships to learn more.

Project mentor

Paul Cullen


Biological Sciences

532 Cooke Hall

Phone: (716)645-4932


Start the project

  1. Email the project mentor using the contact information above to express your interest and get approval to work on the project. (Here are helpful tips on how to contact a project mentor.)
  2. After you receive approval from the mentor to start this project, click the button to start the digital badge. (Learn more about ELN's digital badge options.) 

Preparation activities

The specific preparation activities for this project will be customized through discussions between you and your project mentor. Please be sure to ask them for the instructions to complete the required preparation activities.


Biological Sciences