How Signal Transduction Pathways Regulate Morphogenetic Responses

picture of candida albicans, fungal yeast, round and white.

Seeking students interested in understanding how signal transduction pathways regulate morphogenetic responses as relevant to human health, cancer and other diseases.

Project description

Our lab is interested in understanding how signal transduction pathways regulate morphogenetic responses. We study MAP kinase pathways in fungal species including the model genetic system budding yeast and human pathogen C. albicans. One focus of the lab is to understand how the polarity Rho-type GTPase Cdc42 is activated in the context of a specific MAP kinase pathway. Cdc42 and other proteins can function in multiple pathways. This is part of a general problem surrounding signaling pathways that control specific processes through networks of common or shared factors. How a specific output results from the activation of a common module is not clear and is a problem addressed by our lab. Understanding "signaling specificity" is relevant to human health because cross talk between pathways can lead to cancer and other diseases.

Project outcome

The specific outcomes of this project will be identified by the faculty mentor at the beginning of your collaboration. 

Project details

Timing, eligibility and other details
Length of commitment To be determined by student/mentor
Start time Spring, Summer
Level of collaboration To be determined by student/mentor
Benefits Academic Credit, Work Study
Who is eligible A/B average; hard working, self-motivated
Goldwater and the National Science Foundation

Students participating in this project might be interested in and eligible for the Goldwater Scholarship and the National Science Foundation Graduate Research Fellowship. Connect with the Office of Fellowships and Scholarships to learn more.

Project mentor

Paul Cullen

Professor

Biological Sciences

532 Cooke Hall

Phone: (716)645-4932

Email: pjcullen@buffalo.edu

Start the project

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Fulfilling Academic Major/Minor Requirements

If you are planning to use this project to satisfy program requirements for your academic major or minor, it is your responsibility to obtain approval from your academic department prior to beginning the project. 

Preparation activities

The specific preparation activities for this project will be customized through discussions between you and your project mentor. Please be sure to ask them for the instructions to complete the required preparation activities.