Be the first to characterize a newly discovered ion channel in the cornea of the eye.
The cornea of the eye is a transparent structure that allows the passage of light into the eye. The cornea contains a collagen matrix stroma whose transparency is partially determined by corneal endothelial cells which pump fluid out of the stroma. We are studying the role of SLC4A11, an endothelial cell membrane transporter, in this process. We hypothesize that the SLC4A11 protein is an H+ channel. A student investigator in this project will express SLC4A11 protein in Xenopus frog eggs and then use the excised-patch clamp technique to examine membrane patches from these oocytes for evidence of H+ channel events.
At the end of this project the student will design a poster that will present the project background, goals, data and conclusions. In addition, data acquired by the student may be used in a scientific journal article.
|Length of commitment||Longer than a semester (6-9 months)|
|Level of collaboration||Individual student project|
|Who is eligible||Juniors and Seniors|
Students participating in this project might be interested in and eligible for the Goldwater Scholarship and the National Science Foundation Graduate Research Fellowship. Connect with the Office of Fellowships and Scholarships to learn more.
Department of Physiology and Biophysics. Jacobs School of Medicine & Biomedical Sciences.
Office: 4154. Lab: 4150. 955 Main St. Buffalo, NY 14203
Phone: (716) 829-3111
If you are planning to use this project to satisfy program requirements for your academic major or minor, it is your responsibility to obtain approval from your academic department prior to beginning the project.
Once you begin the digital badge series, you will have access to all the necessary activities and instructions. Your mentor has indicated they would like you to also complete the specific preparation activities below. Please reference this when you get to Step 2 of the Preparation Phase.