Be the first to characterize a newly discovered ion channel in the cornea of the eye.
The cornea of the eye is a transparent structure that allows the passage of light into the eye. The cornea contains a collagen matrix stroma whose transparency is partially determined by corneal endothelial cells which pump fluid out of the stroma. We are studying the role of SLC4A11, an endothelial cell membrane transporter, in this process. We hypothesize that the SLC4A11 protein is an H+ channel. A student investigator in this project will express SLC4A11 protein in Xenopus frog eggs and then use the excised-patch clamp technique to examine membrane patches from these oocytes for evidence of H+ channel events.
At the end of this project the student will design a poster that will present the project background, goals, data and conclusions. In addition, data acquired by the student may be used in a scientific journal article.
|Length of commitment||Longer than a semester (6-9 months)|
|Level of collaboration||Individual student project|
|Who is eligible||Juniors and Seniors|
|Support||Funding is available after the completion of the preparation badge. See below.|
Department of Physiology and Biophysics. Jacobs School of Medicine & Biomedical Sciences.
Office: 4154. Lab: 4150. 955 Main St. Buffalo, NY 14203
Phone: (716) 829-3111
To engage with this project, you will work through a series of Project-Based Collaboration digital badges to guide your experience. These badges will:
All students who wish to participate in a project on the Project Portal must first complete the Project Preparation Digital Badge. First, contact the project mentor to discuss availability and after you’ve received approval, you can start the Project Preparation Digital Badge.
Once you have registered for the Project Preparation Digital Badge, you will receive further instructions related to the activities you will need to complete. In addition, you will also complete the following preparation activities for this particular project: