Investigation of Drug Metabolizing P450 Enzymes
One size does not fit all: a project to investigate individual differences in drug metabolism.
Project description
Cytochrome P450 enzymes play an important role in the detoxification of pharmaceutical drugs and other foreign compounds. However, inherited genetic mutations can make certain P450 enzymes less efficient. This means that "one size does not fit all" when it comes to how individuals from different backgrounds metabolize drugs. This project involves the study at a molecular level of how these mutations alter human drug metabolism.
Project outcome
The project will culminate in a poster presentation in the Spring of the student's senior year. Other outcomes include periodic presentations of data during Estrada lab meetings and, if data are used toward a publication, co-authorship in a peer reviewed journal article.
Project details
| Length of commitment | Year-long |
| Start time | Spring |
| In-person, remote, or hybrid? | In-Person |
| Level of collaboration | Small group project (2-3 students) |
| Benefits | Potential academic credit (through BCH498) |
| Who is eligible | Juniors who have taken BCH403. |
Project mentor
D. Fernando Estrada
Associate Professor
Biochemistry
Phone: (716) 829-2767
Email: dfestrad@buffalo.edu
Start the project
- Email the project mentor using the contact information above to express your interest and get approval to work on the project. (Here are helpful tips on how to contact a project mentor.)
- After you receive approval from the mentor to start this project, click the button to start the digital badge. (Learn more about ELN's digital badge options.)
Preparation activities
Once you begin the digital badge series, you will have access to all the necessary activities and instructions. Your mentor has indicated they would like you to also complete the specific preparation activities below. After you’re approved to begin the project, your mentor will send the relevant materials. Please reference this when you get to Step 2 of the Preparation Phase.
Complete reading of the attached papers.
Keywords
biochemistry, drug metabolism, NMR, structural biology