Feeding in a Model of Prader-Willi Syndrome

Image of immunohistochemical staining of brain tissue.

Image of immunohistochemical staining of brain tissue.

Prader-Willi Syndrome (PWS) is a genetic disorder that involves overeating and weight gain, and we use a rodent model to investigate what drives these changes.

Project is Not Currently Available

This project has reached full capacity for the current term. Please check back next semester for updates.

Project description

Prader-Willi Syndrome (PWS) is a genetic disorder that involves overeating and weight gain. However we currently lack a full understanding of the changes in the brain that drive excessive food intake and body weight changes in this disorder. This project uses a rodent model to evaluate how disruption of a gene thought to be involved in PWS affects energy balance and food reward. This could inform our knowledge of the neural mechanisms that underlie symptoms of PWS.

Students will gain experience collecting and analyzing behavioral and physiological data in rodent models, and will learn about experimental design. They will also learn how to handle rodents and how to measure rats’ food intake and body weight. Students will help out with other ongoing projects in the lab studying neural controls of energy balance in rodents.

Project outcome

The specific outcomes of this project will be identified by the faculty mentor at the beginning of your collaboration. 

Project details

Timing, eligibility and other details
Length of commitment Year-long (10-12 months) 
Start time Summer (May/June of 2022)
In-person, remote, or hybrid? In-person project
Level of collaboration Small group project (2-3 students)
Benefits Research experience, academic credit 
Who is eligible Spphmores, Juniors and Seniors 

Project mentor

Elizabeth G. Mietlicki-Baase

Assistant Professor

Exercise and Nutrition Sciences

G10G Farber Hall

Phone: (716) 645-9156

Email: em1@buffalo.edu

Start the project

  1. Email the project mentor using the contact information above to express your interest and get approval to work on the project. (Here are helpful tips on how to contact a project mentor.)
  2. After you receive approval from the mentor to start this project, click the button to start the digital badge. (Learn more about ELN's digital badge options.) 

Preparation activities

Once you begin the digital badge series, you will have access to all the necessary activities and instructions. Your mentor has indicated they would like you to also complete the specific preparation activities below. Please reference this when you get to Step 2 of the Preparation Phase. 

Students will be required to take relevant trainings offered by UB in animal research and lab safety.