How Blood Vessels Respond to Blood Flow and Matrix Stiffness

image of two blood vessels.

Students will participate in research exploring the cell and molecular mechanisms of responses underlying healthy remodeling and cardiovascular diseases.

Project is Not Currently Available

The project mentor is no longer accepting student inquires, because this project is currently at full capacity. 

Project description

The cells that comprise blood vessels can sense their mechanical environment and respond to changes in blood flow or tissue stiffness with behaviors that can either produce healthy remodeling or contribute to various cardiovascular diseases. Research projects in my lab seek to understand the cell and molecular mechanisms of these responses using a variety of different approaches, including cell culture, microscopy, protein and gene expression assays (Western blots, qPCR, quantitative immunofluorescence), and histology (rodent or rabbit tissues). 

Project outcome

The specific outcomes of this project will be identified by the faculty mentor at the beginning of your collaboration. 

Project details

Timing, eligibility and other details
Length of commitment Variable
Start time Fall, Spring
Level of collaboration Variable
Benefits Work Study, Volunteer
Who is eligible Students studying Biomedical Science, Cell Biology, Biochemistry, Pathology, Histology and/or Biomedical Engineering with basic cell/molecular biology or chemistry lab skills and the ability to work independently
Goldwater and the National Science Foundation

Students participating in this project might be interested in and eligible for the Goldwater Scholarship and the National Science Foundation Graduate Research Fellowship. Connect with the Office of Fellowships and Scholarships to learn more.

Project mentor

John Kolega

Associate Professor

Pathology and Anatomical Sciences

955 Main Street, Room 4258

Phone: (716) 829-3527


Start the project

  1. Email the project mentor using the contact information above to express your interest and get approval to work on the project. (Here are helpful tips on how to contact a project mentor.)
  2. After you receive approval from the mentor to start this project, click the button to start the digital badge. (Learn more about ELN's digital badge options.) 

Preparation activities

The specific preparation activities for this project will be customized through discussions between you and your project mentor. Please be sure to ask them for the instructions to complete the required preparation activities.