Our research focuses on uncovering genetic underlying of cerebral aneurysms and illuminating sex-based disparities through patient samples and a murine mouse mode.
Cerebral aneurysms are more common in women than in men, and women tend to experience worse outcomes. Our lab investigates sex differences in cerebral aneurysms, focusing on genomic variations. We are analyzing blood and tissue samples from aneurysm cases using RNA sequencing and cell culture to investigate gene differences on the X chromosome. Additionally, we are developing a mouse model of cerebral aneurysms to further explore these genomic variations.
This project aims to teach students scientific thinking, essential lab techniques such as qPCR and cell culture, and the process of preparing a manuscript. Highly motivated participants will have opportunities to present their findings at national conferences and take the lead as first authors on peer-reviewed publications.
Length of commitment | About a semester 3-5 months |
Start time | Spring (January/February 2025) Summer (May/June of 2025) |
In-person, remote, or hybrid? | In-Person Project (Can only function with in-person engagement) |
Level of collaboration | Individual Student Project |
Benefits | Stipend Research experience |
Who is eligible | Freshman & Sophomores, lab experience in sciences is highly preferred |
Rosalind Lai
Assistant Professor
Neurosurgery
Phone: (716) 218-2000
Email: puimanro@buffalo.edu
Once you begin the digital badge series, you will have access to all the necessary activities and instructions. Your mentor has indicated they would like you to also complete the specific preparation activities below. Please reference this when you get to Step 2 of the Preparation Phase.
neurosurgery, genetics, aneurysm, neurology, neuroscience, Department of Neurosurgery