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Research Roundtable: Hybrid approach for ClinicalTrials.gov

Research Roundtable graphic on tablet.

University at Buffalo Clinical and Translational Science Institute (CTSI) ClinicalTrials.gov Protocol Registration and Results System Administrators Lynn Jagodzinski, CTSI Clinical Research Regulatory Administrator, and Urmo “Mo” Jaanimägi, CTSI Quality Assurance Specialist, have shared progress of the development of the modernization of ClinicalTrials.gov in previous stories and in the CTSI Translational Spotlight newsletter’s “Research Roundtable” section. Here, they outline some recent updates for users.

Published July 2, 2025

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While the Modernized Protocol Registration and Results System (PRS) has been the primary ClinicalTrials.gov website since August 2024, the classic website is still available, and retirement of the classic version has not been announced. Development of the Modernized PRS is continuing in 2025 and the National Library of Medicine (NLM) will continue to communicate regularly about the progress via Release Notes. 

Currently, Modernized PRS users can create, view, and edit the entire Results Section in the Modernized PRS. However, results still need to be submitted in the Classic PRS. 

Modernized PRS has a number of advantages compared to the Classic PRS, including an enhanced Customizable Record list that provides 44 potential fields of information compared to the 16 in the Classic version.

When to use Classic PRS

ClinicalTrials.gov encourages researchers to use the Modernized PRS. However, users are advised to switch to Classic PRS for critical tasks like:

  • Reviewing and resolving validation errors
  • Entering results
  • Uploading documents and study files

To navigate to Classic PRS, click the blue link on the top center of the webpage that says, “Go to Classic PRS,” as shown below, before completing record updates.

Welcome to modernized PRS.

Educational resources for users

“Fast Forward from ClinicalTrials.gov” is a series of short videos that show users how to perform common tasks on the ClinicalTrials.gov website, including how to perform common tasks on the PRS – both Classic and Modernized versions.

PRS Test environment

The Modernized PRS is available in the sandbox environment where users can explore its features and practice registering and entering results information. PRS Test is for training purposes only, and changes made in PRS Test will not have an effect on the actual PRS. To obtain a PRS Test account, contact ClinicalTrials.gov directly at register@clinicaltrials.gov.

How to get ClinicalTrials.gov help at UB

For UB assistance with ClinicalTrials.gov registration and reporting requirements, contact the UB ClinicalTrials.gov team (UBClinicalTrialsgov@buffalo.edu) or ClinicalTrials.gov PRS Administrators Lynn Jagodzinski (lynnjago@buffalo.edu), CTSI Clinical Research Regulatory Administrator, and Urmo “Mo” Jaanimägi (uj@buffalo.edu), CTSI Quality Assurance Specialist.

For more ClinicalTrials.gov analysis, see the CTSI’s “Research Roundtable” archives here.