Nicotine Delivery from Novel Non-Tobacco Electronic Systems

Goniewicz | Bradizza | Kozlowski
This study investigated various brands and models of electronic nicotine delivery systems to measure nicotine levels in the products, nicotine yields in inhaled vapors, and the levels of nicotine effectively delivered into the bloodstream.

Electronic nicotine delivery systems (ENDS) are novel devices that generate a nicotine-containing vapor which is then inhaled by the user. The most popular ENDS on the market are electronic cigarettes, but different ENDS types and brands are engineered differently. This study investigated various brands and models of ENDS to measure nicotine levels in refill liquids, cartridges, and vapor. Researchers completed laboratory testing to investigate how various engineering characteristics influence nicotine yields inhaled by users of the products, and conducted short- term clinical studies to assess nicotine delivery to the human body from various types of ENDS, including comparisons with conventional cigarettes. The findings can then inform FDA on developing and implementing standard quality assessment procedures and testing methods for ENDS.

Principal Investigator
Maciej Lukasz Goniewicz
Roswell Park Cancer Institute

Clara Bradizza, PhD
Research Institute on Addictions

Lynn Kozlowski, PhD
Department of Community Health and Health Behavior
University at Buffalo

Funding Agency
National Institute on Drug Abuse (NIDA)

Grant Number