TENTATIVE LECTURE SCHEDULE-MIC/BIO 522
Lecture	Date		Topic							Instructor
1	Jan	18	Nomenclature/Structure of Nucleosides							Koudelka
2	Jan	20	Types of double helices-1							Koudelka
3	Jan	23					.ppt file			NO CLASS
4	Jan	25	Types of DNA Double Helices-2							Koudelka
5	Jan	27	DNA Supercoiling				.ppt file	Zechiedrich  et al		Koudelka
6	Jan	30	Protein Structure-alpha helices				textbook	review article		Bianco
7	Feb	1	Protein Structure-beta sheets-super secondary structure							"
8	Feb	3	Types of DNA binding domains-Protein/DNA complexes							"
				Protein motifs		Structure& energy		Nucleosomes
				HTH motif	Protein-DNA interactions			DNA Conform'l Changes		"
				Zn-finger lecture		Znfinger paper 1		Zn finger paper 2		"
9	Feb	6	cont'd	Zipper lecture	winged	zipper	zipper1			"
10	Feb	8	cont'd	Beta ribbon proteins lecture notes						"
11	Feb	10	cont'd	Ob fold lecture	OB-fold review		BRCA	ssDNA binding proteins		"
12	Feb	13	Types of RNA binding domains-Protein/RNA complexes							Ho
13	Feb	15	cont'd							Ho
14	Feb	17	EXAM I
15	Feb	20	Protein Purification tagging							Ho
16	Feb	22	Protein Purification standard methods							Bianco
17	Feb	24	"	"	"					Bianco
18	Feb	27	Nonspecific binding-site selection (McGhee & vonHippel)							Bianco
19	Mar	1	Nonspecific binding-site selection (McGhee & vonHippel)							Koudelka
20	Mar	3	Specific and ionic interactions with DNA (Manning & Record theory)							Koudelka
21	Mar	6	Specific and ionic interactions with DNA (Manning & Record theory)							Koudelka
22	Mar	8	Specific and ionic interactions with DNA (Manning & Record theory)							Koudelka
23	Mar	10	Methods for characterization of Protein-DNA interactions							Koudelka
			Mossing & Record
24	Mar	20	Methods for characterization of Protein-DNA interactions							Koudelka
			Dnase I footprinting-1
			Dnase I footprinting-2
			Kinetics of binding		Dnase I footprinting-3			Nonspecific Complexes
25	Mar	22	Methods for characterization of Protein-DNA interactions							Koudelka
			DMS footprinting		Ethylation interference
26	Mar	24	Methods for characterization of Protein-DNA interactions							Koudelka
27	Mar	27	EXAM II
28	Mar	29	DNA Repair							Huberman
29	Mar	31	DNA Repair							Huberman
30	Apr	3	DNA replication							Ruyechan
31	Apr	5	DNA replication							Ruyechan
32	Apr	7	DNA replication							Ruyechan
33	Apr	10	Transcription-cooperativity							Koudelka
			Lecture Notes		Action at a distance-Theory
			Action at a distance-Example
34	Apr	12	Transcription-cooperativity							Koudelka
			Repression Loops & DNA Flexibility			Corrigendum
35	Apr	14	Transcription-cooperativity							Koudelka
			Mechanisms of cooperative binding
36	Apr	17	Translation & control							Hollingsworth
37	Apr	19	Translation & control							Hollingsworth
38	Apr	21	Recombination							Bianco
39	Apr	24	Recombination							Bianco
40	Apr	26	Recombination							Bianco
41	Apr	28	Nucleic acid transactions							Ho
42	May	1	Nucleic acid transactions							Ho