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Shared Facilities

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Lab of Biochemistry Assistant Professor Michael Buck in the Center of Excellence in Bioinformatics



A wide variety of cutting-edge technology supporting MRBSB research programs exists on both campuses of the University at Buffalo, as well as at the nearby Roswell Park and Hauptman-Woodward Institutes.

These include proteomics and genomics cores, a transgenic mouse core, a macromolecule analysis facility, and a confocal microscopy center. For contact information and capabilities for each of these core facilities, please click on the link below.

Facility Description
Gene Expression Affymetrix The Core provides comprehensive full-service analysis of the genome, transcriptome, and epigenome using state-of-the-art genomic technologies including array and mass spectrometry-based platforms. Robotic infrastructure for performing high throughput population-based studies.
Director: Norma Nowak
Website
Genomics Shared Resource The DNA Microarray and Genomics Facility will afford RPCI investigators a full spectrum of services for parallel analyses of genomes and their expression. Applications include Comparative Genomic Hybridization (CGH) and global gene expression profiling. The facility also maintains and provides a screening and clone characterization service for nine large insert genomic BAC & PAC libraries for human, mouse, rat, and S. Pombe as a resource for RPCI investigators.
Director: Norma Nowak
Website
Gene Targeting and Transgenic Animal Provides services to modify the murine genome by transgenic approaches for the systematic dissection of the genetic, molecular, cellular and physiological mechanisms underlying complex biological processes. The Gene Targeting and Transgenic Facility has the resources and skills necessary to construct mice with defined mutations at specific locations of the mouse genome by in vitro manipulation of embryonic stem (ES) cells by blastocyst injection of altered ES cells.
Co-Directors: Kenneth W. Gross & Steven C. Pruitt
Website
Maldi-Tof / Proteomics The Maldi-Tof facility provides access to mass spectrometric fingerprinting of unknown proteins. Maldi-Tof (Matrix-assisted, Laser-Desorption-Ionization / Time of flight) mass spectrometry is the method of choice for identification of unknown proteins via mass analysis of proteolytic peptides, and for characterization of post-translational modifications.
Director: Ken Blumenthal
Website
Biomolecular Resource Facilities Provides advice and technical assistance to Institute staff in DNA sequencing, quantitative (“real-time”) PCR analysis, the design and synthesis of oligonucleotides and peptides, the isolation, purification and characterization of proteins and peptides, and mass spectrometry.
Director: A. Latif Kazim
Website
Mass Spectrometry This regional research core facility specializes in ultrasensitive quantification of small-molecule drugs and other analytes and full range of proteomics research approaches including expression profiling, proteomic quantification and protein analysis
Director: Robert Straubinger
Website
Confocal Microscopy / Cellular Imaging Provides Zeiss LSM-510 Meta NLO laser scanning confocal microscope services with the capability of simultaneous imaging of multiple-emission wavelengths, transmitted light imaging and multiphoton capability through the addition of a Coherent Chameleon Ultra II laser. Zeiss Axio Observer and Axioimager wide-field fluorescent microscopes are available for bright field, DIC and phase contrast imaging with cooled-CCD and color cameras
Director: Wade J. Sigurdson
Website
Flow Cytometry The facility hosts two analytical flow cytometers and a state of art high-speed cell sorter. The analytical instruments include a BD FACS Calibur four color and a BD FACScan three-color system. The FACS Aria high-speed cell sorter can analyze and select cells based on up to seven fluorescent colors. Multiplex cytokine analysis is performed by the BD FACSArray Bioanalyzer utilizing the cytometric bead array technique
Director: Wade J. Sigurdson
Website
UB North Campus
Imaging Facility
The facility provides access to a Zeiss LSM 710 confocal microscope equipped with a continuous laser and fluorescence lifetime (FLIM) detectors. It also houses a Leica DMIR2 inverted fluorescence microscope equipped with a QImaging Retiga ExiCCD camera and a Hitachi H500 transmission electron microscope.
Contact Person: Alan Siegel
MRI Preclinical Imaging The facility provides heteronuclear magnetic resonance imaging/spectroscopy (MRI/MRS) expertise and facilities to aid in designing, implementing, and analyzing image based research. The 4.7Tesla MR scanner is the first of its kind within a 200-mile radius of Buffalo and should meet the needs of the Consortium and attract users from the community at large.
Director: Richard Mazurchuk
Viral Vector Promotes collaborative translational research, develops and commercializes innovative products and manufactures quality research reagents for the broad life science community.
Director: Te-Chung Lee
Website
Location: 140 Farber Hall South Campus
Clinical Flow Cytometry Provides multiparameter flow cytometry services for clinical diagnosis and follow-up to basic and clinical researchers. Conducts an educational outreach program in flow cytometry. Develops new applications and instrumentation
Contact: Paul Wallace
Website
Location: Roswell Park Cancer Institute
Next Generation Sequencing and Gene Expression Core Offers high-throughput, next-generation sequencing using the Roche/454 Genome Sequencer and Illumina Genome Analyzer platforms. It also provides gene-expression analysis services, including 3’-expresion, miRNA, exon, and gene arrays on Affymetrix platforms.
Director: Norma Nowak
Website
Location: UB New York State Center of Excellence in Bioinformatics and Life Sciences
Histology Core The laboratory is equipped to process tissue for paraffin embedding, section paraffin blocks, and make available a wide variety of routine and special stains. Our facility also has two cryostats for sectioning frozen tissue specimens to facilitate rapid diagnosis, lipid and enzyme demonstration, some immunohistochemical techniques or immunofluorescence work. We also have a JB-4 microtome for cutting methacrylate embedded tissues, but do not currently provide services with this piece of equipment. Since 1980, the Histopathology lab has served the University and Western New York as a full service histology lab available to students, faculty, researchers, and clinicians.
Director: Peter Nickerson
Website
Molecular Interactions BIACORE X System Processing Unit surface Plasmon resonance based technology for studying biomolecular interactions in real time. MicroCal Isothermal Calorimeter quantifies heat released or absorbed in the equilibrium finding of ligand to macromolecular or the interaction between two macromolecules.
Director: Mark Sutton
Website
Protein Production and Crystallization The facility includes a high-throughput screening laboratory that provides rapid screening of 1536 conditions using microbatch under oil crystallization. Six stereomicroscopes are available, two of which are equipped with digital cameras.
Director: George DeTitta
Website
Proteomics & Biopharmaceutical Analysis Core Facility focuses on ultra-sensitive quantification of small-molecule analytes such as drugs, metabolites, and biomolecules; comprehensive protein expression profiling and differential proteome analysis; and ultra-sensitive quantification of proteins/peptides.
Director: Robert Straubinger

Scanning Transmission X-ray Microscopy Provided by the School of Dental Medicine to include secondary electron imaging with magnification up to 100,000X and spatial resolution better than 50 å; backscattered electron imaging of chemical phase difference; qualitative and quantitative elemental analysis with EDS; x-ray imaging—elemental line scans and maps
Director: Peter Bush
Website
X-ray Photoelectron Emission Microscopy Services include operating transmissional electronic microscope; running of 2 light microscopes, consulting regarding feasibility of pilot projects, and training and assisting researchers on using equipment.
Director: Ted Szczesny
Biostatistics Ensures that biostatistical, bioinformatics, and biomathematical support is available to basic, clinical and population-oriented researchers. Services include exploratory data analysis; grant writing (statistical methods sections); hypothesis formulation; experimental design; fitting models to data; simulating data from models; developing customized data mining software and developing novel methods based on emerging technologies.
The goal of BAVR group to develop a sustainable and nationally recognized Biotechnical Analytic Resource for Roswell Park Cancer Institute (RPCI). BAVR will assist in the development and optimal design of nascent biotechnologies at RPCI. A major strength for the BAVR is the ready access to the resources and expertise of the University at Buffalo’s Center for Computational Research (CCR). Specifically BAVR will utilize the CCR’s state of the art parallel computing as well as their extensive expertise in the reconstruction of biological imaging data.
Director: Alan Hutson
Website
Clinical Research Services CRS is an NCI-supported shared resource critical to the submission, implementation, and outcomes of research studies associated with RPCI’s clinical, translational, and basic science research programs by providing oversight of the research process and facilitating the accrual of participants to research studies where integrity, competence, communication, and collaboration are emphasized.
Contact: Joyce M. Yasko
Website
Data Bank and BioRepository (DBBR) Collects and provides de-identified biospecimens and associated epidemiological and clinical data to meet the scientific needs of investigators.
Website
Investigational Drug Services IDS provides expertise in study preparation, pharmacokinetics and drug compounding. Responsible for study drug accountability, storage, and inventory control.
Director: Barbara Todaro
Website
Immunomonitoring Facility (IMF) IMF performs serial monitoring of immunologic function throughout the course of Phase I/Phase II clinical trials in cancer patients.
Director: Sally Schneider
Website
Pathology Resource Network Provides human specimens and laboratory services for basic and translational research to further the understanding of the cellular and molecular pathogenesis of human cancers. The overall mission is to facilitate access to human tissue for investigators with IRB approval with an emphasis on translational efforts.
Director: Carl Morrison
Website
Pharmacokinetics / Pharmacodynamics PK/PD Support clinical research and clinical/pre-clinical drug development by providing state-of-the-art analytical scientific data and PK/PD modeling and simulation services for PK/PD studies of cancer therapeutic and preventive agents with cost effectiveness. Advise on PK/PD study design, sample collection and handling, and guide dose selection for optimizing the therapeutic window of oncology drug products.
Director: Gerald Fetterly
Website
shRNA Core Provides sequence validated human and mouse shRNA libraries in virus vectors. Permits genetic screens and rapid tests for genetic interaction to be performed in mammalian cells. Have also acquired the Human Cancer Retroviral Library that targets all cancer related genes.
Director: Irwin Gelman
Website
Small Molecule Screening Core Provides the possibility of screening chemical libraries in a variety of readout systems for new bioactive compounds, prospective therapeutics, and research tools.
Director: Mikhail Chernov
Website
Survey Research and Data Acquisition Resource (SRDAR) Specializes in cohort and cross-section surveys on tobacco use. Strong portfolio of population-based and clinical-based research, expertise in developing protocols and survey instruments, administers varied types of interviews, clinical trial recruitment and follow-up, protocol development and dissemination of findings.
Director: Andrew Hyland
Website
Bioinformatics Resource Genomic data analysis including CNV/SNP genotype, gene expression (mRNA and miRNA), translational bioinformatics, and nonparametric modeling.
Director: Song Liu
Website
Spectral Karyotyping (SKY/FISH) Services include Spectral Karyotype evaluation of leukemia, solid tumors, and cells lines; evaluation of he dynamic role of chromosomes and genes in cancer cells; genomic validation of cells used in immunology, pharmacology and genetics; assessment of genomic and chromosomal instability; validation of transgenes, gene-knockout and genetically engineered cells; quantification of gene copy number in clinical and transgene research; consultation, data interpretation, training and education.
Website
Pharmaceutical Genetics Laboratory Shared-use facility to provide training and access to state-of-the-art equipment for molecular biology and genomic/genetic analysis.
Director: Daniel Brazeau
X-ray Crystallography Core/High-throughput Crystal Screening Laboratory Provides rapid screening using the microbatch-under-oil crystallization technique and enables crystallographic structure determination of a drug target.
Director:Eaton Lattman
Website
Translational Pharmacology Research Core Provides expertise in pre-clinical, clinical and translational pharmacology and promotes advacing drug discovery to clinical development and post-approval monitoring.
Director: Gene Morse
Website
Laboratory Animal Resources The Laboratory Animal Resource is responsible for the support of biomedical research by promoting the humane care of laboratory animals at Roswell Park Cancer Institute (RPCI). The LAR provides the entire spectrum of animal-related research services including but not limited to specialized animal husbandry, veterinary medical care, diagnostic services, irradiation services, imaging resources and training of investigators and laboratory personnel.
Director: Sandra Buintrago
Division of Comparative Medicine Laboratory Animal Facilities Is a centralized service organization responsible for the animal care and use program. This AAALAC certified facility ensures humane and appropriate animal care, assists principal investigators and their technical personnel, and ensures that the highest standards are met. Includes large animals that serve.
Director: Lisa Martin
Website
Mouse Tumor Model Resources (MTMR) Consolidated resource for maintenance of transgenic breeding colonies, collection and archiving of samples in a murine tumor bank, consultation with experimental design, breeding strategies, and technical expertise in surgical procedures including grafting of human tissue into mice and tissue procurement.
Director: Barbara Foster and Michael Moser
Laboratory for Molecular Visualization and Analysis (LMVA) The mission of the LMVA facility is to provide access to state-of-the-art visualization and computational tools for structural and functional analysis of proteins and nucleic acids, and for the design of synthetic ligands and drugs. The facility is designed provide ready access to major commercial and open source software on high performance graphics and computing platforms, which are located in close proximity to many of the research laboratories in which basic biochemical, proteomic, genomic, and pharmaceutical research is conducted.
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Department of Social & Preventive Medicine (SPM) Biological Specimen Bank The facility houses specimens collected as part of epidemiological studies and clinical trials conducted in SPM. A complex, secure computerized mapping system tracks the specimens and a sophisticated back-up system maintains integrity. The SPM bio-bank currently houses well over 1 million samples from over 25,000 participants, which in conjunction with the specimen bank at RPCI and the future biobank in the CTRC provides a novel resource for translational science.
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